Mostrar el registro sencillo del ítem

Pilot study on accelerated aging in lupus using epigenetic biomarkers of age

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorGENSOUS, Noemie
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorBLANCO, Patrick
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorLAZARO, Estibaliz
dc.contributor.authorMERCIE, Patrick
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPELLEGRIN, Isabelle
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorRICHEZ, Christophe
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDUFFAU, Pierre
dc.date.accessioned2024-09-19T12:18:33Z
dc.date.available2024-09-19T12:18:33Z
dc.date.issued2023
dc.identifier.issn0961-2033en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201691
dc.description.abstractEnObjective: Despite an important increase in lifespan over the last decades, patients with systemic lupus erythematosus (SLE) still have to face a high morbi-mortality, particularly related to cardiovascular diseases, infections and cancers. Such events are more commonly found during old age in the general population, raising the hypothesis of an acceleration of the aging process in SLE patients. In this pilot study, we wanted to test the hypothesis that SLE would be associated with an accelerated biological aging measured by the epigenetic clocks models. Methods: We applied DNA methylation-based biomarkers of age in publicly available datasets of SLE patients. For every SLE patient and control included in the dataset, we calculated their epigenetic age and a measure of epigenetic age acceleration, according to Horvath’s epigenetic clock model. Results: We included in our analysis two distinct DNA methylation datasets of 30 subjects (among which 15 with SLE) and 55 subjects (among which 30 with SLE), respectively. In both datasets, there was a statistically significant correlation between chronological age and epigenetic age. We did not observe any statistically significant difference in the measure of epigenetic age acceleration between SLE patients and controls. Conclusion: We did not observe any evidence of an accelerated biological aging in SLE patients, according to Horvath’s epigenetic clock model.
dc.language.isoENen_US
dc.subject.enSystemic lupus erythematosus
dc.subject.enAging
dc.subject.enBiomarkers
dc.title.enPilot study on accelerated aging in lupus using epigenetic biomarkers of age
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/09612033221130976en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed36179673en_US
bordeaux.journalLupusen_US
bordeaux.page129-135en_US
bordeaux.volume32en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04702568
hal.version1
hal.date.transferred2024-09-19T12:18:36Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Lupus&rft.date=2023&rft.volume=32&rft.issue=1&rft.spage=129-135&rft.epage=129-135&rft.eissn=0961-2033&rft.issn=0961-2033&rft.au=GENSOUS,%20Noemie&BLANCO,%20Patrick&LAZARO,%20Estibaliz&MERCIE,%20Patrick&PELLEGRIN,%20Isabelle&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem