Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion
| dc.rights.license | open | en_US |
| dc.contributor.author | SONI, Chetna | |
| dc.contributor.author | MAKITA, Sohei | |
| dc.contributor.author | EICHINGER, Anna | |
| dc.contributor.author | SERPAS, Lee | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | SISIRAK, Vanja | |
| dc.contributor.author | REIZIS, Boris | |
| dc.date.accessioned | 2024-09-17T11:42:04Z | |
| dc.date.available | 2024-09-17T11:42:04Z | |
| dc.date.issued | 2023-11 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201624 | |
| dc.description.abstractEn | Autoantibodies to chromatin and dsDNA are a hallmark of systemic lupus erythematosus (SLE). In a mouse model of monogenic human SLE caused by DNASE1L3 deficiency, the anti-DNA response is dependent on endosomal nucleic acid-sensing TLRs TLR7 and TLR9. In this study, we report that this response also required TLR2, a surface receptor for microbial products that is primarily expressed on myeloid cells. Cell transfers into lymphopenic DNASE1L3-deficient mice showed that TLR2 was required for anti-DNA Ab production by lymphocytes. TLR2 was detectably expressed on B cells and facilitated the production of IL-6 by B cells activated in the presence of microbial products. Accordingly, treatment with broadspectrum antibiotics or Ab-mediated blockade of IL-6 delayed the anti-DNA response in DNASE1L3-deficient mice. These studies reveal an unexpected B cell_intrinsic role of TLR2 in systemic autoreactivity to DNA, and they suggest that microbial products may synergize with self- DNA in the activation of autoreactive B cells in SLE | |
| dc.language.iso | EN | en_US |
| dc.title.en | Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.4049/jimmunol.2300313 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 37800687 | en_US |
| bordeaux.journal | Journal of Immunology | en_US |
| bordeaux.page | 1475-1480 | en_US |
| bordeaux.volume | 211 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 10 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Immunology&rft.date=2023-11&rft.volume=211&rft.issue=10&rft.spage=1475-1480&rft.epage=1475-1480&rft.au=SONI,%20Chetna&MAKITA,%20Sohei&EICHINGER,%20Anna&SERPAS,%20Lee&SISIRAK,%20Vanja&rft.genre=article |
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