Mostrar el registro sencillo del ítem

Cutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion

dc.rights.licenseopenen_US
dc.contributor.authorSONI, Chetna
dc.contributor.authorMAKITA, Sohei
dc.contributor.authorEICHINGER, Anna
dc.contributor.authorSERPAS, Lee
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorSISIRAK, Vanja
dc.contributor.authorREIZIS, Boris
dc.date.accessioned2024-09-17T11:42:04Z
dc.date.available2024-09-17T11:42:04Z
dc.date.issued2023-11
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201624
dc.description.abstractEnAutoantibodies to chromatin and dsDNA are a hallmark of systemic lupus erythematosus (SLE). In a mouse model of monogenic human SLE caused by DNASE1L3 deficiency, the anti-DNA response is dependent on endosomal nucleic acid-sensing TLRs TLR7 and TLR9. In this study, we report that this response also required TLR2, a surface receptor for microbial products that is primarily expressed on myeloid cells. Cell transfers into lymphopenic DNASE1L3-deficient mice showed that TLR2 was required for anti-DNA Ab production by lymphocytes. TLR2 was detectably expressed on B cells and facilitated the production of IL-6 by B cells activated in the presence of microbial products. Accordingly, treatment with broadspectrum antibiotics or Ab-mediated blockade of IL-6 delayed the anti-DNA response in DNASE1L3-deficient mice. These studies reveal an unexpected B cell_intrinsic role of TLR2 in systemic autoreactivity to DNA, and they suggest that microbial products may synergize with self- DNA in the activation of autoreactive B cells in SLE
dc.language.isoENen_US
dc.title.enCutting Edge: TLR2 Signaling in B Cells Promotes Autoreactivity to DNA via IL-6 Secretion
dc.typeArticle de revueen_US
dc.identifier.doi10.4049/jimmunol.2300313en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed37800687en_US
bordeaux.journalJournal of Immunologyen_US
bordeaux.page1475-1480en_US
bordeaux.volume211en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Immunology&rft.date=2023-11&rft.volume=211&rft.issue=10&rft.spage=1475-1480&rft.epage=1475-1480&rft.au=SONI,%20Chetna&MAKITA,%20Sohei&EICHINGER,%20Anna&SERPAS,%20Lee&SISIRAK,%20Vanja&rft.genre=article


Archivos en el ítem

ArchivosTamañoFormatoVer

No hay archivos asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem