Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials
| dc.rights.license | open | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | PICHAVANT, Loïc | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| dc.contributor.author | CARRIÉ, Hélène | |
| dc.contributor.author | DURRIEU, Marie-Christine | |
| hal.structure.identifier | Laboratoire de Chimie des Polymères Organiques [LCPO] | |
| hal.structure.identifier | Team 1 LCPO : Polymerization Catalyses & Engineering | |
| dc.contributor.author | HÉROGUEZ, Valérie | |
| dc.date.accessioned | 2020 | |
| dc.date.available | 2020 | |
| dc.date.issued | 2016 | |
| dc.identifier.issn | 1759-9954 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/20155 | |
| dc.description.abstractEn | Antibiotic functionalized polymeric nanoparticles (NPs) are obtained by the copolymerization of macromonomers, which is a powerful way to synthesize bioactive biomaterial surfaces able to fight a bacterial strain in the case of infection. The active molecule loading can be modulated/increased by the use of highly charged macromonomers (typically polyhydroxylated macromonomers). This paper presents the synthesis of α-norbornenyl hydroxylated macromonomers (polyglycidol and poly(ethylene oxide)-block-polyglycidol) functionalized with an antibiotic: gentamicin sulfate. Then, these macromonomers are copolymerized with norbornene (Nb) by ring-opening metathesis polymerization in a dispersion to form core–shell NPs which have application as antibiotic platforms for the synthesis of bioactive biomaterial surfaces. | |
| dc.language.iso | en | |
| dc.publisher | Royal Society of Chemistry - RSC | |
| dc.title.en | Nanoparticles highly loaded with gentamicin sulfate by a combination of polyhydroxylated macromonomers and ROMP for the synthesis of bioactive biomaterials | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1039/C6PY01774F | |
| dc.subject.hal | Chimie/Polymères | |
| bordeaux.journal | Polymer Chemistry | |
| bordeaux.page | 7019-7028 | |
| bordeaux.volume | 7 | |
| bordeaux.hal.laboratories | Laboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629 | * |
| bordeaux.issue | 45 | |
| bordeaux.institution | Bordeaux INP | |
| bordeaux.institution | Université de Bordeaux | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-01416279 | |
| hal.version | 1 | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-01416279v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Polymer%20Chemistry&rft.date=2016&rft.volume=7&rft.issue=45&rft.spage=7019-7028&rft.epage=7019-7028&rft.eissn=1759-9954&rft.issn=1759-9954&rft.au=PICHAVANT,%20Lo%C3%AFc&CARRI%C3%89,%20H%C3%A9l%C3%A8ne&DURRIEU,%20Marie-Christine&H%C3%89ROGUEZ,%20Val%C3%A9rie&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||