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Impact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates

dc.rights.licenseopenen_US
dc.contributor.authorMARC, Aurélien
dc.contributor.authorMARLIN, Romain
dc.contributor.authorDONATI, Flora
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPRAGUE, Melanie
dc.contributor.authorKERIOUI, Marion
dc.contributor.authorHÉRATE, Cécile
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorALEXANDRE, Marie
dc.contributor.authorDEREUDDRE-BOSQUET, Nathalie
dc.contributor.authorBERTRAND, Julie
dc.contributor.authorCONTRERAS, Vanessa
dc.contributor.authorBEHILLIL, Sylvie
dc.contributor.authorMAISONNASSE, Pauline
dc.contributor.authorVAN DER WERF, Sylvie
dc.contributor.authorLE GRAND, Roger
dc.contributor.authorGUEDJ, Jérémie
dc.date.accessioned2024-09-12T06:53:05Z
dc.date.available2024-09-12T06:53:05Z
dc.date.issued2023-08-09
dc.identifier.issn1553-734Xen_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201555
dc.description.abstractEnThe impact of variants of concern (VoC) on SARS-CoV-2 viral dynamics remains poorly understood and essentially relies on observational studies subject to various sorts of biases. In contrast, experimental models of infection constitute a powerful model to perform controlled comparisons of the viral dynamics observed with VoC and better quantify how VoC escape from the immune response. Here we used molecular and infectious viral load of 78 cynomolgus macaques to characterize in detail the effects of VoC on viral dynamics. We first developed a mathematical model that recapitulate the observed dynamics, and we found that the best model describing the data assumed a rapid antigen-dependent stimulation of the immune response leading to a rapid reduction of viral infectivity. When compared with the historical variant, all VoC except beta were associated with an escape from this immune response, and this effect was particularly sensitive for delta and omicron variant (p<10-6 for both). Interestingly, delta variant was associated with a 1.8-fold increased viral production rate (p = 0.046), while conversely omicron variant was associated with a 14-fold reduction in viral production rate (p<10-6). During a natural infection, our models predict that delta variant is associated with a higher peak viral RNA than omicron variant (7.6 log10 copies/mL 95% CI 6.8-8 for delta; 5.6 log10 copies/mL 95% CI 4.8-6.3 for omicron) while having similar peak infectious titers (3.7 log10 PFU/mL 95% CI 2.4-4.6 for delta; 2.8 log10 PFU/mL 95% CI 1.9-3.8 for omicron). These results provide a detailed picture of the effects of VoC on total and infectious viral load and may help understand some differences observed in the patterns of viral transmission of these viruses.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enImpact of variants of concern on SARS-CoV-2 viral dynamics in non-human primates
dc.title.alternativePLoS Comput Biolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1371/journal.pcbi.1010721en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37556476en_US
bordeaux.journalPLoS Computational Biologyen_US
bordeaux.pagee1010721en_US
bordeaux.volume19en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.teamSISTM_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDBill and Melinda Gates Foundationen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=PLoS%20Computational%20Biology&amp;rft.date=2023-08-09&amp;rft.volume=19&amp;rft.issue=8&amp;rft.spage=e1010721&amp;rft.epage=e1010721&amp;rft.eissn=1553-734X&amp;rft.issn=1553-734X&amp;rft.au=MARC,%20Aur%C3%A9lien&amp;MARLIN,%20Romain&amp;DONATI,%20Flora&amp;PRAGUE,%20Melanie&amp;KERIOUI,%20Marion&amp;rft.genre=article


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