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Stabilization of Mycoplasma bovis surfaceome using CRISPR-based genome editing

hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorHOGAN, Patrick
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorRIDEAU, Fabien
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorLARTIGUE, Carole
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBLANCHARD, Alain
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorSIRAND-PUGNET, Pascal
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorBEVEN, Laure
hal.structure.identifierInteractions hôtes-agents pathogènes [Toulouse] [IHAP]
dc.contributor.authorBARANOWSKI, Eric
hal.structure.identifierBiologie du fruit et pathologie [BFP]
dc.contributor.authorARFI, Yonathan
dc.date.conference2023-07-19
dc.description.abstractEnAmong the minimal bacteria belonging to the genus Mycoplasma, several of them are recognized pathogens for a wide diversity of animals. Mycoplasma bovis is one of the most significant species infecting dairy and fattening cows, causing mastitis and pneumonia, respectively. Attempts to control the disease has led to mass culling and costs of hundreds of millions in treatments and compensation worldwide as current vaccines are still considered poorly effective. Our objective is to develop efficient genetic tools for M. bovis genome engineering tools to gain knowledge on the pathogen and pave the way for the development of rationally designed synthetic vaccines. We are currently developing CRISPR-based and synthetic biology tools to target virulence factors and optimize antigenic presentation. Such tools will be useful to build a vaccine chassis that would allow presentation of selected epitopes at the cell surface, leading to an improved immune response. Here we report the inactivation of the recombinase implicated in the highly frequent variation of surface proteins expressed by M. bovis that allow this pathogen to remain elusive. By neutralizing one of the main weapons in the M. bovis arsenal, this result is a main step toward the stabilization of the bacterial surfaceome and the development of an effective vaccine chassis.
dc.description.sponsorshipApproche rationnelle d'un vaccin Mycoplasma bovis - ANR-21-CE35-0008
dc.language.isoen
dc.title.enStabilization of Mycoplasma bovis surfaceome using CRISPR-based genome editing
dc.typeAutre communication scientifique (congrès sans actes - poster - séminaire...)
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Microbiologie et Parasitologie
bordeaux.conference.titleBioSynSys2023
bordeaux.countryFR
bordeaux.conference.cityToulouse
bordeaux.peerReviewedoui
hal.identifierhal-04693886
hal.version1
hal.invitednon
hal.proceedingsnon
hal.conference.end2023-07-21
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-04693886v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.au=HOGAN,%20Patrick&RIDEAU,%20Fabien&LARTIGUE,%20Carole&BLANCHARD,%20Alain&SIRAND-PUGNET,%20Pascal&rft.genre=conference


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