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Different Trajectories of Apathy and Depression Among Subjective Cognitive Impairment Individuals with or without Conversion to Dementia

dc.rights.licenseopenen_US
dc.contributor.authorBOGDAN, Anamaria
dc.contributor.authorFABRE, Roxane
dc.contributor.authorDESMIDT, Thomas
dc.contributor.authorGOLEBIOWSKI, Jérôme
dc.contributor.authorTOPIN, Jérémie
dc.contributor.authorBETHUS, Ingrid
dc.contributor.authorHANON, Olivier
dc.contributor.authorBOUTOLEAU-BRETONNIERE, Claire
dc.contributor.authorWAGEMANN, Nathalie
dc.contributor.authorANNWEILER, Cédric
dc.contributor.authorOUSSET, Pierre-Jean
dc.contributor.authorGODEFROY, Olivier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorROUCH, Isabelle
dc.contributor.authorPACCALIN, Marc
dc.contributor.authorSUKHORUKOVA, Maryana
dc.contributor.authorGABELLE, Audrey
dc.contributor.authorROBERT, Gabriel
dc.contributor.authorDAVID, Renaud
dc.date.accessioned2024-09-11T13:57:42Z
dc.date.available2024-09-11T13:57:42Z
dc.date.issued2023-09-01
dc.identifier.issn1387-2877en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201523
dc.description.abstractEnBackground: Apathy and depression are two early behavioral symptoms in Alzheimer's disease (AD) and related disorders that often occur prior to the onset of cognitive decline and memory disturbances. Both have been associated with an increased risk of conversion to dementia, with a distinct neuropathology. Objective: The assessment of the trajectories of apathy and depression and their independent impact on dementia conversion. Methods: Apathy and Depression were measured using the Neuropsychiatric Inventory for caregiver (NPI) and clinician (NPI-C), among the nondemented individuals reporting subjective cognitive decline (SCD) at baseline. They were followed up over a 60-month period. Some converted to dementia, according to the methodology carried out by the French Memento Cohort. Results: Among individuals with SCD (n = 2,323), the levels of apathy and depression were low and did not evolve significantly over the 60-month period, despite a trend in apathy increasing as of month 24. Regarding SCD individuals who converted to dementia within the 60-month period (n = 27), the prevalence of depression remained globally steady, while the levels of apathy increased over time. Conclusion: Apathy and depression have different trajectories among individuals with SCD and apathy alone is more likely-compared to depression-to be associated with conversion to dementia.
dc.language.isoENen_US
dc.subject.endementia
dc.subject.enAlzheimer's disease
dc.subject.enapathy
dc.subject.enbehavioral and psychological symptoms
dc.subject.endepression
dc.title.enDifferent Trajectories of Apathy and Depression Among Subjective Cognitive Impairment Individuals with or without Conversion to Dementia
dc.title.alternativeJ Alzheimers Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.3233/JAD-230162en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37545236en_US
bordeaux.journalJournal of Alzheimer's Diseaseen_US
bordeaux.page415-426en_US
bordeaux.volume95en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Alzheimer's%20Disease&rft.date=2023-09-01&rft.volume=95&rft.issue=2&rft.spage=415-426&rft.epage=415-426&rft.eissn=1387-2877&rft.issn=1387-2877&rft.au=BOGDAN,%20Anamaria&FABRE,%20Roxane&DESMIDT,%20Thomas&GOLEBIOWSKI,%20J%C3%A9r%C3%B4me&TOPIN,%20J%C3%A9r%C3%A9mie&rft.genre=article


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