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History of learning disorders is associated with worse cognitive and functional outcomes in schizophrenia: results from the multicentric FACE-SZ cross-sectional dataset

dc.rights.licenseopenen_US
dc.contributor.authorDONDE, Clement
dc.contributor.authorDUBERTRET, Caroline
dc.contributor.authorFOND, Guillaume
dc.contributor.authorANDRE, Myrtille
dc.contributor.authorBERNA, Fabrice
dc.contributor.authorBOYER, Laurent
dc.contributor.authorCAPDEVIELLE, Delphine
dc.contributor.authorCHEREAU, Isabelle
dc.contributor.authorCOULON, Nathalie
dc.contributor.authorDOREY, Jean-Michel
dc.contributor.authorLEIGNIER, Sylvain
dc.contributor.authorLLORCA, Pierre-Michel
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorMISDRAHI, David
dc.contributor.authorPASSERIEUX, Christine
dc.contributor.authorPIGNON, Baptiste
dc.contributor.authorREY, Romain
dc.contributor.authorSCHORR, Benoit
dc.contributor.authorSCHURHOFF, Franck
dc.contributor.authorURBACH, Mathieu
dc.contributor.authorPOLOSAN, Mircea
dc.contributor.authorMALLET, Jasmina
dc.date.accessioned2024-09-09T08:42:20Z
dc.date.available2024-09-09T08:42:20Z
dc.date.issued2023-12
dc.identifier.issn0940-1334en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201495
dc.description.abstractEnSchizophrenia is associated with early neurodevelopmental disorders, including most frequently learning disorders (LD), among them dyslexia and dyspraxia. Despite the demonstrated links between schizophrenia and LD, specific clinical patterns of the schizophrenia with a history of LD subgroup remain unknown. The aim of the present study was to investigate cognitive impairment, symptoms and functional outcome associated with a history of LD in a large cross-sectional, multicentric, sample of schizophrenia subjects. 492 community-dwelling subjects with schizophrenia (75.6% male, mean age 30.8 years) were consecutively included in the network of the FondaMental Expert Centers for Schizophrenia in France and received a thorough clinical assessment. The 51 (10.4%) subjects identified with a history of LD had significantly impaired general cognitive ability (Wechsler Adult Intelligence Scale Full Scale Total IQ: Cohen's d = 0.50, p = 0.001), processing speed (d = 0.19), verbal comprehension (d = 0.29), working memory (d = 0.31), cognitive inhibition and flexibility (d = 0.26), central executive functioning (d = 0.26), phonemic verbal fluency (d = 0.22) and premorbid intellectual ability (d = 0.48), as well as with a worse functional outcome (Global Assessment of Functioning, d = 0.21), independently of age, sex, education level, symptoms, treatments, and addiction comorbidities. These results indicate that a history of LD is associated with later cognitive impairment and functional outcome in schizophrenia. This suggests that history of LD is a relevant clinical marker to discriminate subgroups of patients with schizophrenia with different profiles in a precision psychiatry framework.
dc.description.sponsorshipSorbonne Universités à Paris pour l'Enseignement et la Rechercheen_US
dc.language.isoENen_US
dc.subject.enMental health
dc.subject.enPsychiatry
dc.subject.enNeurodevelopment
dc.subject.enIntellectual quotient
dc.title.enHistory of learning disorders is associated with worse cognitive and functional outcomes in schizophrenia: results from the multicentric FACE-SZ cross-sectional dataset
dc.title.alternativeEur Arch Psychiatry Clin Neuroscien_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00406-022-01544-zen_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed36583738en_US
bordeaux.journalEuropean Archives of Psychiatry and Clinical Neuroscienceen_US
bordeaux.page1773-1783en_US
bordeaux.volume273en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDFondation FondaMentalen_US
bordeaux.identifier.funderIDAssistance publique-Hôpitaux de Parisen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Archives%20of%20Psychiatry%20and%20Clinical%20Neuroscience&rft.date=2023-12&rft.volume=273&rft.issue=8&rft.spage=1773-1783&rft.epage=1773-1783&rft.eissn=0940-1334&rft.issn=0940-1334&rft.au=DONDE,%20Clement&DUBERTRET,%20Caroline&FOND,%20Guillaume&ANDRE,%20Myrtille&BERNA,%20Fabrice&rft.genre=article


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