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dc.rights.licenseopenen_US
hal.structure.identifierStatistics In System biology and Translational Medicine [SISTM]
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPRAGUE, Melanie
dc.date.accessioned2024-09-05T08:14:27Z
dc.date.available2024-09-05T08:14:27Z
dc.date.issued2023-07
dc.date.conference2023-07-02
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201446
dc.description.abstractEnModel informed drug development has potentially a great deal to offer for vaccine development and in particular in seeking methods to extrapolate effectiveness. The definition of correlates of protection is critical for the development of next generation SARS-CoV-2 vaccine platforms. The complete chains of causality and interrelationships between vaccination, immune responses, protection and clinical endpoints are likely to be considerably complex. In this work, we propose a model-based approach for identifying mechanistic correlates of protection against disease acquisition based on mathematical modeling of viral dynamics and data mining of immunological markers. We apply the method to three different studies in non-human primates evaluating SARS-CoV-2 vaccines based on CD40-targeting, two-component spike nanoparticle and mRNA 1273. Inhibition of RBD binding to ACE2 appears to be a robust mechanistic correlate of protection across the three vaccine platforms although not capturing the whole biological vaccine effect. https://wcp2023.org/events/pharmacometric-model-informed-drug-development-in-infectious-diseases/
dc.language.isoENen_US
dc.title.enPharmacometric modelling to inform vaccine development
dc.typeCommunication dans un congrèsen_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionINRIAen_US
bordeaux.conference.title19th World Congress of Basic & Clinical Pharmacology 2023en_US
bordeaux.countrygben_US
bordeaux.teamSISTM_BPHen_US
bordeaux.conference.cityGlasgowen_US
hal.proceedingsnonen_US
hal.conference.end2023-07-07
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.date=2023-07&rft.au=PRAGUE,%20Melanie&rft.genre=unknown


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