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Cytomegalovirus DNAemia Requiring (Val)Ganciclovir Treatment for More Than 8 Weeks Is a Key Factor in the Development of Antiviral Drug Resistance
| dc.rights.license | open | en_US |
| dc.contributor.author | ACQUIER, M. | |
| dc.contributor.author | TATON, B. | |
| dc.contributor.author | ALAIN, S. | |
| dc.contributor.author | GARRIGUE, I. | |
| dc.contributor.author | MARY, J. | |
| dc.contributor.author | PFIRMANN, P. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | VISENTIN, Jonathan | |
| dc.contributor.author | HANTZ, S. | |
| dc.contributor.author | MERVILLE, P. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | KAMINSKI, Hannah | |
| dc.contributor.author | COUZI, L. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | MERVILLE, Pierre | |
| dc.date.accessioned | 2024-08-27T08:44:13Z | |
| dc.date.available | 2024-08-27T08:44:13Z | |
| dc.date.issued | 2023 | |
| dc.identifier.issn | 2328-8957 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201312 | |
| dc.description.abstractEn | Background: Prolonged (val)ganciclovir [(V)GCV] exposure for ≥6 weeks is a known predisposing factor for cytomegalovirus (CMV) drug resistance. However, the selection of this threshold was based on limited data. In this study, we sought to reappraise the risk factors for the development of (V)GCV resistance through a specific focus on kidney transplant recipients (KTRs). Methods: This single-center retrospective study included 313 consecutive KTRs treated for a first CMV episode. Adjusted Cox multivariate regression analysis was used for identifying independent risk factors. Results: Antiviral drug resistance was identified in 20 (6%) KTRs. A cumulative (V)GCV exposure for more than 6 weeks (regardless of the viral load) was not associated with antiviral drug resistance (hazard ratio [HR] = 2.45, 95% confidence interval [CI] = 0.33-18.30, P =. 38). In contrast, persistent CMV DNAemia requiring (V)GCV treatment for more than 8 weeks was the main independent risk factor for antiviral drug resistance (HR = 11.68, 95% CI = 2.62-52.01, P =. 001). The (V)GCV treatment for more than 8 weeks was given to 9% and 18% of patients who had persistent or recurrent CMV DNAemia, respectively. These scenarios were associated with the occurrence of drug resistance in 39% and 12% of cases, respectively. Conclusions: Cumulative (V)GCV exposure ≥6 weeks regardless of the viral load is not associated with antiviral drug resistance. In contrast, prolonged exposure to (V)GCV during CMV replication (with a cutoff ³8 weeks) seems to be a key factor. © 2023 The Author(s). Published by Oxford University Press on behalf of Infectious Diseases Society of America. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | Antiviral drug resistance | |
| dc.subject.en | Cytomegalovirus | |
| dc.subject.en | Kidney transplantation | |
| dc.subject.en | (val)ganciclovir | |
| dc.title.en | Cytomegalovirus DNAemia Requiring (Val)Ganciclovir Treatment for More Than 8 Weeks Is a Key Factor in the Development of Antiviral Drug Resistance | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ofid/ofad018 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 36817745 | en_US |
| bordeaux.journal | Open Forum Infectious Diseases | en_US |
| bordeaux.volume | 10 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.issue | 2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-04678532 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-08-27T08:44:15Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | CC BY-NC-ND | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Open%20Forum%20Infectious%20Diseases&rft.date=2023&rft.volume=10&rft.issue=2&rft.eissn=2328-8957&rft.issn=2328-8957&rft.au=ACQUIER,%20M.&TATON,%20B.&ALAIN,%20S.&GARRIGUE,%20I.&MARY,%20J.&rft.genre=article |
