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dc.rights.licenseopenen_US
dc.contributor.authorDEMOLY, Pascal
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOLIMARD, Mathieu
dc.contributor.authorBERGMANN, Jean-Francois
dc.contributor.authorDELAISI, Bertrand
dc.contributor.authorGOUVERNEUR, Amandine
dc.contributor.authorVADEL, Jade
dc.contributor.authorCOLLIN, Cedric
dc.contributor.authorGIRARD, Laurence
dc.contributor.authorSCURATI, Silvia
dc.contributor.authorDEVILLIER, Philippe
dc.date.accessioned2024-08-22T14:22:52Z
dc.date.available2024-08-22T14:22:52Z
dc.date.issued2024-06-01
dc.identifier.issn2666-7762en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201270
dc.description.abstractEnBACKGROUND: The only disease-modifying treatment currently available for allergic rhinitis (AR) is allergen immunotherapy (AIT). The main objective of the EfficAPSI real-world study (RWS) was to evaluate the impact of liquid sublingual immunotherapy (SLIT-liquid) on asthma onset and evolution in AR patients. METHODS: An analysis with propensity score weighting was performed using the EfficAPSI cohort, comparing patients dispensed SLIT-liquid with patients dispensed AR symptomatic medication with no history of AIT (controls). Index date corresponded to the first dispensation of either treatment. The sensitive definition of asthma event considered the first asthma drug dispensation, hospitalisation or long-term disease (LTD) for asthma, the specific one omitted drug dispensation and the combined one considered omalizumab or three ICS ± LABA dispensation, hospitalisation or LTD. In patients with pre-existing asthma, the GINA treatment step-up evolution was analysed. FINDINGS: In this cohort including 112,492 SLIT-liquid and 333,082 controls, SLIT-liquid exposure was associated with a significant lower risk of asthma onset vs. control, according to all definitions (combined: HR [95% CI] = 0.62 [0.60-0.63], sensitive: 0.77 [0.76-0.78], and specific: 0.67 [0.61-0.72]). Exposure to SLIT was associated with a one-third reduction in GINA step-up regardless baseline steps. INTERPRETATION: In this national RWS with the largest number of person-years of follow-up to date in the field of AIT, SLIT-liquid was associated with a significant reduction in the risk of asthma onset or worsening. The use of three definitions (sensitive or specific) and GINA step-up reinforced the rigorous methodology, substantiating SLIT-liquid evidence as a causal treatment option for patients with respiratory allergies. FUNDING: Stallergenes Greer.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAllergic
dc.subject.enAsthma
dc.subject.enPrecision medicine
dc.subject.enRhinitis
dc.subject.enSublingual immunotherapy
dc.title.enImpact of liquid sublingual immunotherapy on asthma onset and progression in patients with allergic rhinitis: a nationwide population-based study (EfficAPSI study)
dc.title.alternativeLancet Reg Health Euren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.lanepe.2024.100915en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38707866en_US
bordeaux.journalThe Lancet Regional Health - Europeen_US
bordeaux.page100915en_US
bordeaux.volume41en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=The%20Lancet%20Regional%20Health%20-%20Europe&rft.date=2024-06-01&rft.volume=41&rft.spage=100915&rft.epage=100915&rft.eissn=2666-7762&rft.issn=2666-7762&rft.au=DEMOLY,%20Pascal&MOLIMARD,%20Mathieu&BERGMANN,%20Jean-Francois&DELAISI,%20Bertrand&GOUVERNEUR,%20Amandine&rft.genre=article


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