Afficher la notice abrégée

Metabolic causes of liver disease among adults living with HIV from low- and middle-income countries: a cross-sectional study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorPLAISY, Marie Kerbie
dc.contributor.authorMINGA, Albert K.
dc.contributor.authorWANDELER, Gilles
dc.contributor.authorMURENZI, Gad
dc.contributor.authorSAMALA, Niharika
dc.contributor.authorROSS, Jeremy
dc.contributor.authorLOPEZ, Alvaro
dc.contributor.authorMENSAH, Ephrem
dc.contributor.authorDE WAAL, Renee
dc.contributor.authorKUNIHOLM, Mark H.
dc.contributor.authorDIERO, Lameck
dc.contributor.authorSALVI, Sonali
dc.contributor.authorMOREIRA, Rodrigo
dc.contributor.authorATTIA, Alain
dc.contributor.authorMANDIRIRI, Ardele
dc.contributor.authorSHUMBUSHO, Fabienne
dc.contributor.authorGOODRICH, Suzanne
dc.contributor.authorRUPASINGHE, Dhanushi
dc.contributor.authorALARCON, Paola
dc.contributor.authorMARURI, Fernanda
dc.contributor.authorPERRAZO, Hugo
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorJAQUET, Antoine
dc.date.accessioned2024-08-21T07:47:18Z
dc.date.available2024-08-21T07:47:18Z
dc.date.issued2024-04-01
dc.identifier.issn1758-2652en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201211
dc.description.abstractEnIntroductionLiver disease is a leading cause of morbidity and mortality among persons living with HIV (PLHIV). While chronic viral hepatitis has been extensively studied in low- and middle-income countries (LMICs), there is limited information about the burden of metabolic disorders on liver disease in PLHIV.MethodsWe conducted a cross-sectional analysis of baseline data collected between October 2020 and July 2022 from the IeDEA-Sentinel Research Network, a prospective cohort enrolling PLHIV >= 40 years on antiretroviral treatment (ART) for >= 6 months from eight clinics in Asia, Americas, and central, East, southern and West Africa. Clinical assessments, laboratory testing on fasting blood samples and liver stiffness measurement (LSM)/controlled attenuation parameter (CAP) by vibration-controlled transient elastography were performed. Multivariable logistic regression models assessed factors associated with liver fibrosis (LSM >= 7.1 kPa) and steatosis (CAP >= 248 dB/m). Population attributable fraction (PAF) of each variable associated with significant liver fibrosis was estimated using Levin's formula.ResultsOverall, 2120 PLHIV (56% female, median age 50 [interquartile range: 45-56] years) were included. The prevalence of obesity was 19%, 12% had type 2 diabetes mellitus (T2DM), 29% had hypertension and 53% had dyslipidaemia. The overall prevalence of liver fibrosis and steatosis was 7.6% (95% confidence interval [CI] 6.1-8.4) and 28.4% (95% CI 26.5-30.7), respectively, with regional variability. Male sex at birth (odds ratio [OR] 1.62, CI 1.10-2.40), overweight/obesity (OR = 2.50, 95% CI 1.69-3.75), T2DM (OR 2.26, 95% CI 1.46-3.47) and prolonged exposure to didanosine (OR 3.13, 95% CI 1.46-6.49) were associated with liver fibrosis. Overweight/obesity and T2DM accounted for 42% and 11% of the PAF for liver fibrosis, while HBsAg and anti-HCV accounted for 3% and 1%, respectively. Factors associated with steatosis included overweight/obesity (OR 4.25, 95% CI 3.29-5.51), T2DM (OR 2.06, 95% CI 1.47-2.88), prolonged exposure to stavudine (OR 1.69, 95% CI 1.27-2.26) and dyslipidaemia (OR 1.68, 95% CI 1.31-2.16).ConclusionsMetabolic disorders were significant risk factors for liver disease among PLHIV in LMICs. Early recognition of metabolic disorders risk factors might be helpful to guide clinical and lifestyle interventions. Further prospective studies are needed to determine the causative natures of these findings.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enHIV acquisition
dc.subject.enAntiretroviral therapy
dc.subject.enLiver disease
dc.subject.enLiver fibrosis
dc.subject.enLow‐ and middle‐income countries
dc.subject.enMetabolic disorders
dc.title.enMetabolic causes of liver disease among adults living with HIV from low- and middle-income countries: a cross-sectional study
dc.title.alternativeJ Int AIDS Socen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jia2.26238en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38566493en_US
bordeaux.journalJournal of the International Aids Societyen_US
bordeaux.pagee26238en_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04674256
hal.version1
hal.date.transferred2024-08-21T07:47:23Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20International%20Aids%20Society&rft.date=2024-04-01&rft.volume=27&rft.issue=4&rft.spage=e26238&rft.epage=e26238&rft.eissn=1758-2652&rft.issn=1758-2652&rft.au=PLAISY,%20Marie%20Kerbie&MINGA,%20Albert%20K.&WANDELER,%20Gilles&MURENZI,%20Gad&SAMALA,%20Niharika&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
BPH_JIntAIDSSoc_2024_Plaisy.pdf
Taille:
1.294Mo
Format:
PDF
Voir/Ouvrir
Thumbnail
Nom:
license_rdf
Taille:
914octets
Format:
application/rdf+xml
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée