Mostrar el registro sencillo del ítem
Metabolic causes of liver disease among adults living with HIV from low- and middle-income countries: a cross-sectional study
dc.rights.license | open | en_US |
hal.structure.identifier | Bordeaux population health [BPH] | |
hal.structure.identifier | Global Health in the Global South [GHiGS] | |
dc.contributor.author | PLAISY, Marie Kerbie | |
dc.contributor.author | MINGA, Albert K. | |
dc.contributor.author | WANDELER, Gilles | |
dc.contributor.author | MURENZI, Gad | |
dc.contributor.author | SAMALA, Niharika | |
dc.contributor.author | ROSS, Jeremy | |
dc.contributor.author | LOPEZ, Alvaro | |
dc.contributor.author | MENSAH, Ephrem | |
dc.contributor.author | DE WAAL, Renee | |
dc.contributor.author | KUNIHOLM, Mark H. | |
dc.contributor.author | DIERO, Lameck | |
dc.contributor.author | SALVI, Sonali | |
dc.contributor.author | MOREIRA, Rodrigo | |
dc.contributor.author | ATTIA, Alain | |
dc.contributor.author | MANDIRIRI, Ardele | |
dc.contributor.author | SHUMBUSHO, Fabienne | |
dc.contributor.author | GOODRICH, Suzanne | |
dc.contributor.author | RUPASINGHE, Dhanushi | |
dc.contributor.author | ALARCON, Paola | |
dc.contributor.author | MARURI, Fernanda | |
dc.contributor.author | PERRAZO, Hugo | |
hal.structure.identifier | Bordeaux population health [BPH] | |
hal.structure.identifier | Global Health in the Global South [GHiGS] | |
dc.contributor.author | JAQUET, Antoine | |
dc.date.accessioned | 2024-08-21T07:47:18Z | |
dc.date.available | 2024-08-21T07:47:18Z | |
dc.date.issued | 2024-04-01 | |
dc.identifier.issn | 1758-2652 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201211 | |
dc.description.abstractEn | IntroductionLiver disease is a leading cause of morbidity and mortality among persons living with HIV (PLHIV). While chronic viral hepatitis has been extensively studied in low- and middle-income countries (LMICs), there is limited information about the burden of metabolic disorders on liver disease in PLHIV.MethodsWe conducted a cross-sectional analysis of baseline data collected between October 2020 and July 2022 from the IeDEA-Sentinel Research Network, a prospective cohort enrolling PLHIV >= 40 years on antiretroviral treatment (ART) for >= 6 months from eight clinics in Asia, Americas, and central, East, southern and West Africa. Clinical assessments, laboratory testing on fasting blood samples and liver stiffness measurement (LSM)/controlled attenuation parameter (CAP) by vibration-controlled transient elastography were performed. Multivariable logistic regression models assessed factors associated with liver fibrosis (LSM >= 7.1 kPa) and steatosis (CAP >= 248 dB/m). Population attributable fraction (PAF) of each variable associated with significant liver fibrosis was estimated using Levin's formula.ResultsOverall, 2120 PLHIV (56% female, median age 50 [interquartile range: 45-56] years) were included. The prevalence of obesity was 19%, 12% had type 2 diabetes mellitus (T2DM), 29% had hypertension and 53% had dyslipidaemia. The overall prevalence of liver fibrosis and steatosis was 7.6% (95% confidence interval [CI] 6.1-8.4) and 28.4% (95% CI 26.5-30.7), respectively, with regional variability. Male sex at birth (odds ratio [OR] 1.62, CI 1.10-2.40), overweight/obesity (OR = 2.50, 95% CI 1.69-3.75), T2DM (OR 2.26, 95% CI 1.46-3.47) and prolonged exposure to didanosine (OR 3.13, 95% CI 1.46-6.49) were associated with liver fibrosis. Overweight/obesity and T2DM accounted for 42% and 11% of the PAF for liver fibrosis, while HBsAg and anti-HCV accounted for 3% and 1%, respectively. Factors associated with steatosis included overweight/obesity (OR 4.25, 95% CI 3.29-5.51), T2DM (OR 2.06, 95% CI 1.47-2.88), prolonged exposure to stavudine (OR 1.69, 95% CI 1.27-2.26) and dyslipidaemia (OR 1.68, 95% CI 1.31-2.16).ConclusionsMetabolic disorders were significant risk factors for liver disease among PLHIV in LMICs. Early recognition of metabolic disorders risk factors might be helpful to guide clinical and lifestyle interventions. Further prospective studies are needed to determine the causative natures of these findings. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | HIV acquisition | |
dc.subject.en | Antiretroviral therapy | |
dc.subject.en | Liver disease | |
dc.subject.en | Liver fibrosis | |
dc.subject.en | Low‐ and middle‐income countries | |
dc.subject.en | Metabolic disorders | |
dc.title.en | Metabolic causes of liver disease among adults living with HIV from low- and middle-income countries: a cross-sectional study | |
dc.title.alternative | J Int AIDS Soc | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1002/jia2.26238 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 38566493 | en_US |
bordeaux.journal | Journal of the International Aids Society | en_US |
bordeaux.page | e26238 | en_US |
bordeaux.volume | 27 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 4 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | GHIGS_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | National Institutes of Health | en_US |
bordeaux.identifier.funderID | Institut de Recherche pour le Développement | en_US |
hal.identifier | hal-04674256 | |
hal.version | 1 | |
hal.date.transferred | 2024-08-21T07:47:23Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20the%20International%20Aids%20Society&rft.date=2024-04-01&rft.volume=27&rft.issue=4&rft.spage=e26238&rft.epage=e26238&rft.eissn=1758-2652&rft.issn=1758-2652&rft.au=PLAISY,%20Marie%20Kerbie&MINGA,%20Albert%20K.&WANDELER,%20Gilles&MURENZI,%20Gad&SAMALA,%20Niharika&rft.genre=article |