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Associations of circulating vitamins with 10-year retinal neurodegeneration: the Alienor Study
dc.rights.license | open | en_US |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | MERLE, Benedicte
ORCID: 0000-0003-1332-0954 | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | SCHWEITZER, Cedric | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | ROUGIER, Marie-Benedicte | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | GREGOIRE, Audrey
ORCID: 0000-0002-1494-5764 | |
dc.contributor.author | GAYRAUD, Laure | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DELYFER, Marie-Noelle | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | KOROBELNIK, Jean-Francois
ORCID: 0000-0002-4438-9535 IDREF: 028739272 | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | DELCOURT, Cecile | |
dc.date.accessioned | 2024-08-20T14:41:27Z | |
dc.date.available | 2024-08-20T14:41:27Z | |
dc.date.issued | 2024-06-10 | |
dc.identifier.issn | 1760-4788 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/201204 | |
dc.description.abstractEn | OBJECTIVE: To investigate the associations between circulating vitamins A, D, E, B6, B9, B12 and longitudinal changes in retinal nerve fiber layer (RNFL) thickness. METHODS: The Alienor study, a prospective population-based cohort (Bordeaux, France), includes 963 individuals aged 73 years or older at baseline. The present study included 646 participants with complete RNFL measurement and vitamins. Study period is from 2009 to 2020. Peripapillary RNFL thickness was measured using spectral domain optical coherence tomography (SD-OCT). Plasma vitamins A, D and E and, serum vitamins B6, B9 and B12 were measured from blood sample. We performed linear mixed models, adjusted for age, gender, axial length, family history of glaucoma, and alcohol consumption to evaluated associations between vitamins and RNFL thickness changes over time. RESULTS: Individuals having higher concentrations of vitamin E, D and B9 had a slower RNFL thinning during the 10-years of follow-up. Indeed, a 1-standard deviation (SD) increase of vitamin E (10.8 μmol/L), D (17.6 nmol/L) and B9 (11 μmol/L) were associated with slower RNFL thinning by 0.14 μm/year (95% confidence interval (CI), 0.03-0.25, p = 0.01), 0.14 μm/year (95% CI, 0.02-0.27, p = 0.02) and 0.11 μm/year (95% CI: 0.007-0.21, p = 0.04), respectively. No significant associations were observed for vitamins A, B6 and B12 with RNFL thinning. CONCLUSIONS: Higher levels of vitamins E, D and B9 were associated with a slower RNFL thickness on SD-OCT over time, suggesting that those vitamins may contribute to the neuroprotection of the retina. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | Cohort | |
dc.subject.en | Neurodegeneration | |
dc.subject.en | Nutrition | |
dc.subject.en | Retina | |
dc.subject.en | Retinal nerve fiber layer (RNFL) | |
dc.subject.en | Vitamins | |
dc.title.en | Associations of circulating vitamins with 10-year retinal neurodegeneration: the Alienor Study | |
dc.title.alternative | J Nutr Health Aging | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.jnha.2024.100286 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 38861880 | en_US |
bordeaux.journal | Journal of Nutrition, Health & Aging | en_US |
bordeaux.page | 100286 | en_US |
bordeaux.volume | 28 | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.issue | 8 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | LEHA_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Fondation Voir et Entendre | en_US |
bordeaux.identifier.funderID | Ministère de la Santé | en_US |
bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
hal.identifier | hal-04673915 | |
hal.version | 1 | |
hal.date.transferred | 2024-08-20T14:41:30Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
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