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Tailoring the pore structure of iron oxide core@stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and applicability to anti-cancer therapies

dc.rights.licenseopenen_US
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorBIZEAU, Joëlle
hal.structure.identifierCentre de Recherches en Cancérologie de Toulouse [CRCT]
dc.contributor.authorJOURNAUX-DUCLOS, Justine
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorKIEFER, Céline
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorFREIS, Barbara
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorIHIAWAKRIM, Dris
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorRAMIREZ, Maria De Los Angeles
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorLUCANTE, Théo
hal.structure.identifierInstitut de chimie et procédés pour l'énergie, l'environnement et la santé [ICPEES]
dc.contributor.authorPARKHOMENKO, Ksenia
hal.structure.identifierInstitut de Chimie de Clermont-Ferrand [ICCF]
dc.contributor.authorVICHERY, Charlotte
hal.structure.identifierLaboratoire de physique et chimie des nano-objets [LPCNO]
dc.contributor.authorCARREY, Julian
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
IDREF: inp
hal.structure.identifierInstitut Pluridisciplinaire Hubert Curien [IPHC]
dc.contributor.authorBERTAGNOLLI, Caroline
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorERSEN, Ovidiu
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorBÉGIN-COLIN, Sylvie
hal.structure.identifierCentre de Recherches en Cancérologie de Toulouse [CRCT]
dc.contributor.authorGIGOUX, Véronique
hal.structure.identifierInstitut de Physique et Chimie des Matériaux de Strasbourg [IPCMS]
dc.contributor.authorMERTZ, Damien
dc.date.accessioned2024-08-20T08:02:53Z
dc.date.available2024-08-20T08:02:53Z
dc.date.issued2024-07-09
dc.identifier.issn2040-3364en_US
dc.identifier.otherhttps://doi.org/10.57745/SVCWSIen_US
dc.identifier.urioai:crossref.org:10.1039/d4nr01388c
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201189
dc.description.abstractEnCore–shell nanocomposites made of iron oxide core (IO NPs) coated with mesoporous silica (MS) shells are promising theranostic agents. While the core is being used as an efficient heating nanoagent under alternating magnetic field (AMF) and near infra-red (NIR) light and as a suitable contrast agent for magnetic resonance imaging (MRI), the MS shell is particularly relevant to ensure colloidal stability in a biological buffer and to transport a variety of therapeutics. However, a major challenge with such inorganic nanostructures is the design of adjustable silica structures, especially with tunable large pores which would be useful, for instance, for the delivery of large therapeutic biomolecule loading and further sustained release. Furthermore, the effect of tailoring a porous silica structure on the magneto- or photothermal dissipation still remains poorly investigated. In this work, we undertake an in-depth investigation of the growth of stellate mesoporous silica (STMS) shells around IO NPs cores and of their micro/mesoporous features respectively through time-lapse and in situ liquid phase transmission electron microscopy (LPTEM) and detailed nitrogen isotherm adsorption studies. We found here that the STMS shell features (thickness, pore size, surface area) can be finely tuned by simply controlling the sol–gel reaction time, affording a novel range of IO@STMS core@shell NPs. Finally, regarding the responses under alternating magnetic fields and NIR light which are evaluated as a function of the silica structure, IO@STMS NPs having a tunable silica shell structure are shown to be efficient as T2-weighted MRI agents and as heating agents for magneto- and photoinduced hyperthermia. Furthermore, such IO@STMS are found to display anti-cancer effects in pancreatic cancer cells under magnetic fields (both alternating and rotating).
dc.description.sponsorshipNANOCOMPOSITES INNOVANTS LIBÉRANT DES FACTEURS BIOLOGIQUES PAR HYPERTHERMIE MAGNÉTIQUE EN TANT QUE COMPOSANTS DE MATRICES INTELLIGENTES POUR L'INGÉNIERIE TISSULAIRE - ANR-19-CE09-0004en_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-ShareAlike 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-sa/3.0/us/*
dc.sourcecrossref
dc.title.enTailoring the pore structure of iron oxide core@stellate mesoporous silica shell nanocomposites: effects on MRI and magnetic hyperthermia properties and applicability to anti-cancer therapies
dc.typeArticle de revueen_US
dc.identifier.doi10.1039/d4nr01388cen_US
dc.subject.halChimie/Matériauxen_US
dc.identifier.pubmed39104307en_US
bordeaux.journalNanoscaleen_US
bordeaux.pageDOI: 10.1039/D4NR01388Cen_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629en_US
bordeaux.hal.laboratoriesInstitut de Physique et Chimie des Matériaux de Strasbourg (IPCMS) - UMR 7504 CNRS / Université de Strasbourgen_US
bordeaux.hal.laboratoriesInstitut de Chimie des Procédés pour l'Energie, l'Environnement et la Santé (ICPEES) - UMR 7515 CNRS / Université de Strasbourgen_US
bordeaux.hal.laboratoriesLaboratoire de Physique et Chimie des Nano-Objets (LPCNO) - UMR 5215 Université de Toulouse Paul Sabatier, CNRS, INSA Toulouseen_US
bordeaux.hal.laboratoriesCentre de Recherches en Cancérologie de Toulouse (CRCT) - UMR 1037 CNRS / Inserm / Université de Toulouse Paul Sabatieren_US
bordeaux.hal.laboratoriesInstitut Pluridisciplinaire Hubert Curien (IPHC) - UMR 7178 CNRS / Université de Strasbourgen_US
bordeaux.hal.laboratoriesInstitut de Chimie de Clermont-Ferrand (ICCF) - UMR 6296 Université Clermont Auvergne, Clermont Auvergne INP, CNRSen_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04673341
hal.version1
hal.date.transferred2024-08-20T08:02:58Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccCC BY-NC-SAen_US
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