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Thermo-therapie non invasive des organes abdominaux

dc.rights.licenseopen
hal.structure.identifierInstitut de Mathématiques de Bordeaux [IMB]
dc.contributor.authorDENIS DE SENNEVILLE, Baudouin
hal.structure.identifierUniversity Medical Center [Utrecht]
dc.contributor.authorRIES, Mario
hal.structure.identifierImagerie moléculaire et fonctionnelle: de la physiologie à la thérapie
dc.contributor.authorQUESSON, Bruno
hal.structure.identifierHôpital Saint-André
dc.contributor.authorTRILLAUD, Hervé
hal.structure.identifierImasonic SAS [Voray sur l’Ognon]
dc.contributor.authorBERRIET, Remi
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorFLEURY, Gérard
hal.structure.identifierUniversity Medical Center [Utrecht]
dc.contributor.authorMOONEN, Chrit
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2011
dc.identifier.issn1959-0318
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20117
dc.description.abstractEnObjective: Thermal therapies are rapidly gaining importance in oncology as an alternative to radio-therapy and surgery. The possibility to locally deposit thermal energy in a non-invasive way opens a path towards new therapeutic strategies with improved reliability and reduced associated trauma leading to improved efficacy, reduced hospitalisation and costs. Liver and kidney tumors represent a major health problem because not allpatients are suitable for curative treatment with surgery. Currently, radio-frequency is the most used method for percutaneous ablation and the development of a completely non-invasive method based on MR guided high intensity focused ultrasound (HIFU) treatments is of particular interest, since the energy source is located outside the body. This project addressed technological challenges for the treatment of liver and kidney, related to their motion and their location within the thoracic cage.Material and methods: This project proposed safe and non-invasive methods for MR-guided thermal ablation of malignant tumors of liver and kidney with HIFU. Real-time MRI was used to precisely control heat deposition with HIFU within the targeted pathological area despite the motion of these organs, in order to provide an effective treatment with a reduced duration and an increased level of safety for the patient. New technologies were studied for the development of matrix transducers able to generate high acoustic power.Discussion: 3D Real-Time MRI guidance of a HIFU intervention as well as inter-costal firing were realized in vivo in pig liver during breathing under real-time MR thermometry over sustained periods of several minutes. The ability to generate acoustic power as high as up to five time the usual level was demonstrated in vitro thanks to the development of the new transducer technology proposed in this project.Conclusion: A fully MR-integrated HIFU treatment platform dedicated to the treatment of cancer in mobile abdominal organs was developed.
dc.language.isoen
dc.publisherElsevier Masson
dc.titleThermo-therapie non invasive des organes abdominaux
dc.title.enNon-invasive thermo-therapy of abdominal organs
dc.typeArticle de revue
dc.subject.halSciences de l'ingénieur [physics]/Traitement du signal et de l'image
bordeaux.journalInnovation and Research in BioMedical engineering
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01534658
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01534658v1
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