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Care interruptions and mortality among adults in Europe and North America

dc.rights.licenseopenen_US
dc.contributor.authorTRICKEY, Adam
dc.contributor.authorZHANG, Lei
dc.contributor.authorRENTSCH, Christopher T
dc.contributor.authorPANTAZIS, Nikos
dc.contributor.authorIZQUIERDO, Rebeca
dc.contributor.authorANTINORI, Andrea
dc.contributor.authorLEIERER, Gisela
dc.contributor.authorBURKHOLDER, Greer
dc.contributor.authorCAVASSINI, Matthias
dc.contributor.authorPALACIO-VIEIRA, Jorge
dc.contributor.authorGILL, M John
dc.contributor.authorTEIRA, Ramon
dc.contributor.authorSTEPHAN, Christoph
dc.contributor.authorOBEL, Niels
dc.contributor.authorVEHRESCHILD, Jorg-Janne
dc.contributor.authorSTERLING, Timothy R
dc.contributor.authorVAN DER VALK, Marc
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorCRANE, Heidi M
dc.contributor.authorSILVERBERG, Michael J
dc.contributor.authorINGLE, Suzanne M
dc.contributor.authorSTERNE, Jonathan A
dc.contributor.authorANTIRETROVIRAL THERAPY COHORT, Collaboration
dc.date.accessioned2024-07-19T13:26:57Z
dc.date.available2024-07-19T13:26:57Z
dc.date.issued2024-08-01
dc.identifier.issn1473-5571en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/201038
dc.description.abstractEnOBJECTIVE: Interruptions in care of people with HIV (PWH) on antiretroviral therapy (ART) are associated with adverse outcomes, but most studies have relied on composite outcomes. We investigated whether mortality risk following care interruptions differed from mortality risk after first starting ART. DESIGN: Collaboration of 18 European and North American HIV observational cohort studies of adults with HIV starting ART between 2004-2019. METHODS: Care interruptions were defined as gaps in contact of ≥365 days, with a subsequent return to care (distinct from loss to follow-up), or ≥270 days and ≥545 days in sensitivity analyses. Follow-up time was allocated to no/pre-interruption or post-interruption follow-up groups. We used Cox regression to compare hazards of mortality between care interruption groups, adjusting for time-updated demographic and clinical characteristics and biomarkers upon ART initiation or re-initiation of care. RESULTS: Of 89197 PWH, 83.4% were male and median age at ART start was 39 years (interquartile range [IQR]: 31-48). 8654 PWH (9.7%) had ≥1 care interruption; 10913 episodes of follow-up following a care interruption were included. There were 6104 deaths in 536,334 person-years, a crude mortality rate of 11.4 (95%CI: 11.1-11.7) per 1000 person-years. The adjusted mortality hazard ratio (HR) for the post-interruption group was 1.72 (95%CI: 1.57-1.88) compared with the no/pre-interruption group. Results were robust to sensitivity analyses assuming ≥270-day (HR 1.49, 95%CI: 1.40-1.60) and ≥545-day (HR 1.67, 95%CI: 1.48-1.88) interruptions. CONCLUSIONS: Mortality was higher among PWH reinitiating care following an interruption, compared with when PWH initially start ART, indicating the importance of uninterrupted care.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.title.enCare interruptions and mortality among adults in Europe and North America
dc.title.alternativeAIDSen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/qad.0000000000003924en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38742863en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.page1533-1542en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue10en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04654374
hal.version1
hal.date.transferred2024-07-19T13:27:00Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2024-08-01&rft.volume=38&rft.issue=10&rft.spage=1533-1542&rft.epage=1533-1542&rft.eissn=1473-5571&rft.issn=1473-5571&rft.au=TRICKEY,%20Adam&ZHANG,%20Lei&RENTSCH,%20Christopher%20T&PANTAZIS,%20Nikos&IZQUIERDO,%20Rebeca&rft.genre=article


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