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Monocore vs multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia

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hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorHEMERY, Gauvin
hal.structure.identifierImagerie moléculaire et thérapies innovantes en oncologie [IMOTION]
dc.contributor.authorGENEVOIS, Coralie
hal.structure.identifierImagerie moléculaire et thérapies innovantes en oncologie [IMOTION]
dc.contributor.authorCOUILLAUD, Franck
hal.structure.identifierPôle Microscopie Electronique
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorLACOMME, Sabrina
hal.structure.identifierPôle Microscopie Electronique
hal.structure.identifierBordeaux Imaging Center [BIC]
dc.contributor.authorGONTIER, Etienne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn2058-9689
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20081
dc.description.abstractEnPEGylated magnetic iron oxide nanoparticles (IONPs) were synthesised with the aim to provide proof of concept results of remote cancer cell killing by magnetic fluid hyperthermia. The IONPs were produced by the polyol synthetic route also called “forced hydrolysis pathway” yielding highly superparamagnetic, readily-dispersible, and biocompatible IONPs. As shown previously, adjusting parameters of the reaction led to either monocore or multicore IONPs, with on-demand morphology and magnetic properties. Polyethylene glycol (PEG) was grafted onto the nanoparticles in a single final step, using a phosphonic acid-terminated PEG synthesised separately, a strategy named “convergent”. The magnetic properties of the IONPs were preserved in physiological media thanks to this biocompatible shell. The interaction of the PEGylated IONPs with a glioblastoma cell line was studied, from the stability of IONPs in appropriate cell culture medium to the remotely magnetically triggered cell death. Cellular internalisation of the IONPs was studied, along with their fate after application of an alternating magnetic field (AMF). This investigation highlights the superior efficiency of multicore (nanoflowers) vs monocore (nanospheres) IONPs for magnetic hyperthermia, leading to 80 % cancer cells death in medically translatable conditions.
dc.description.sponsorshipMagnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017
dc.description.sponsorshipDéveloppment d'une infrastructure française distribuée coordonnée - ANR-10-INBS-04-01/10-INBS-0004
dc.language.isoen
dc.publisherRSC
dc.subject.enLysosomal membrane permeability
dc.subject.enNanotoxicology
dc.subject.enBioluminescence Imaging
dc.subject.enMagnetic hyperthermia
dc.subject.enCellular uptake
dc.subject.enMagnetic nanoparticles MNPs
dc.title.enMonocore vs multicore magnetic iron oxide nanoparticles: uptake by glioblastoma cells and efficiency for magnetic hyperthermia
dc.typeArticle de revue
dc.identifier.doi10.1039/C7ME00061H
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.description.sponsorshipEuropeMultifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy
bordeaux.journalMolecular Systems Design & Engineering
bordeaux.page629-639
bordeaux.volume2
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue5
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01628901
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01628901v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Molecular%20Systems%20Design%20&%20Engineering&rft.date=2017&rft.volume=2&rft.issue=5&rft.spage=629-639&rft.epage=629-639&rft.eissn=2058-9689&rft.issn=2058-9689&rft.au=HEMERY,%20Gauvin&GENEVOIS,%20Coralie&COUILLAUD,%20Franck&LACOMME,%20Sabrina&GONTIER,%20Etienne&rft.genre=article


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