Determinants of serious health outcome-free status in middle-aged and older people with dysglycaemia: Exploratory analysis of the ORIGIN trial.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| dc.contributor.author | HESS, Sibylle | |
| dc.contributor.author | MCQUEEN, Matthew | |
| dc.contributor.author | PIGEYRE, Marie | |
| dc.contributor.author | LEE, Shun Fu | |
| dc.contributor.author | PARE, Guillaume | |
| dc.contributor.author | GERSTEIN, Hertzel C | |
| dc.date.accessioned | 2024-07-05T13:18:49Z | |
| dc.date.available | 2024-07-05T13:18:49Z | |
| dc.date.issued | 2024-05-15 | |
| dc.identifier.issn | 1463-1326 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200761 | |
| dc.description.abstractEn | To assess clinical and biochemical measurements that can identify people with dysglycaemia (i.e. diabetes or pre-diabetes) who remain free of serious outcomes during follow-up. We conducted exploratory analyses using data from the Outcomes Reduction with an Initial Glargine Intervention (ORIGIN) study to identify independent determinants of outcome-free status in 12 537 middle-aged and older adults with prediabetes and early type 2 diabetes from 40 countries. Serious outcome-free status was defined as the absence of major cardiovascular outcomes, kidney or retinal outcomes, peripheral artery disease, dementia, cancer, any hospitalization, or death during follow-up. In total, 3328 (26.6%) participants remained free of serious outcomes during a median follow-up of 6.2 years (IQR 5.8, 6.7). Independent clinical determinants of outcome-free status included younger age, female sex, non-White ethnicity, shorter diabetes duration, absence of previous cardiovascular disease, current or former smokers, higher grip strength, Mini-Mental State Examination score, and ankle-brachial index, lower body mass index and kidney disease index, and non-use of renin-angiotensin system drugs and beta-blockers. In a subset of 8401 people with baseline measurements of 238 biomarkers, growth differentiation factor 15, kidney injury molecule-1, N-terminal pro-brain natriuretic peptide, uromodulin, C-reactive protein, factor VII and ferritin were independent determinants. The combination of clinical determinants and biomarkers best identified participants who remained outcome-free (C-statistics 0.71, 95% confidence interval 0.70-0.73; net reclassification improvement 0.55, 95% confidence interval 0.48-0.58). A set of routinely measured clinical characteristics and seven protein biomarkers identify middle-aged and older people with prediabetes or early type 2 diabetes as least likely to experience serious outcomes during follow-up. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | cancer; cardiovascular disease; dysglycaemia; kidney disease; retinopathy; type 2 diabetes. | |
| dc.title.en | Determinants of serious health outcome-free status in middle-aged and older people with dysglycaemia: Exploratory analysis of the ORIGIN trial. | |
| dc.title.alternative | Diabetes Obes Metab | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/dom.15654 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Médecine humaine et pathologie | en_US |
| dc.identifier.pubmed | 38747213 | en_US |
| bordeaux.journal | Diabetes, Obesity and Metabolism | en_US |
| bordeaux.hal.laboratories | Biologie des maladies cardiovasculaires (BMC) - UMR 1034 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04636971 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-07-05T13:18:51Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diabetes,%20Obesity%20and%20Metabolism&rft.date=2024-05-15&rft.eissn=1463-1326&rft.issn=1463-1326&rft.au=MOHAMMEDI,%20Kamel&HESS,%20Sibylle&MCQUEEN,%20Matthew&PIGEYRE,%20Marie&LEE,%20Shun%20Fu&rft.genre=article |
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