Genome-Wide Investigation of Exogenous Female Hormones, Genetic Variation, and Venous Thromboembolism Risk
dc.rights.license | open | en_US |
dc.contributor.author | HASSER, Emily K | |
dc.contributor.author | BRODY, Jennifer A | |
dc.contributor.author | BARTZ, Traci M | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | THIBORD, Florian | |
dc.contributor.author | LI-GAO, Ruifang | |
dc.contributor.author | KAUKO, Anni | |
dc.contributor.author | WIGGINS, Kerri L | |
dc.contributor.author | TEDER-LAVING, Maris | |
dc.contributor.author | KIM, Jihye | |
dc.contributor.author | MUNSCH, Gaelle | |
dc.contributor.author | HAILE, Helen G | |
dc.contributor.author | DELEUZE, Jean-Francois | |
dc.contributor.author | VAN HYLCKAMA VLIEG, Astrid | |
dc.contributor.author | WOLBERG, Alisa S | |
dc.contributor.author | BOLAND, Anne | |
dc.contributor.author | MORANGE, Pierre-Emmanuel | |
dc.contributor.author | FINNGEN, Estonia Biobank Research Team | |
dc.contributor.author | KRAFT, Peter | |
dc.contributor.author | LOWENSTEIN, Charles J | |
dc.contributor.author | EMMERICH, Joseph | |
dc.contributor.author | SITLANI, Colleen M | |
dc.contributor.author | SUCHON, Pierre | |
dc.contributor.author | ROSENDAAL, Frits R | |
dc.contributor.author | NIIRANEN, Teemu | |
dc.contributor.author | KABRHEL, Christopher | |
hal.structure.identifier | Bordeaux population health [BPH] | |
dc.contributor.author | TREGOUET, David-Alexandre | |
dc.contributor.author | SMITH, Nicholas L | |
dc.date.accessioned | 2024-06-27T08:56:09Z | |
dc.date.available | 2024-06-27T08:56:09Z | |
dc.date.issued | 2024-05-21 | |
dc.identifier.issn | 1538-7836 | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200669 | |
dc.description.abstractEn | BACKGROUND: Increased risk of venous thromboembolism (VTE) is a life-threatening side effect for users of oral contraceptives (OCs) or hormone therapy (HT). OBJECTIVES: To investigate the potential for genetic predisposition to VTE in OC or HT users, we conducted a gene-by-environment (GxE) case-only meta-analysis of genome-wide association studies (GWAS). METHODS: Use or non-use of OCs (7 studies) or HT (8 studies) at the time of the VTE event was determined by pharmacy records or self-report. A synergy index (SI) was modeled for each variant in each study and estimated supra-multiplicative GxE interaction. The SI parameters were first meta-analyzed across OC and HT studies, and subsequently meta-analyzed to obtain an overall estimate. The primary analysis was agnostic GWAS and interrogated all imputed genotypes using a p-value threshold of <5.0x10(-8); secondary analyses were candidate-based. RESULTS: The VTE case-only OC meta-analysis included 2,895 OC users and 6,607 non-users; the case-only HT meta-analysis included 2,434 HT users and 12,793 non-users. In primary GWAS meta-analyses, no variant reached genome-wide significance, but the smallest p-value approached statistical significance: rs9386463 (p = 5.03x10(-8)). We tested associations for 138 candidate variants and identified 2 that exceeded statistical significance (0.05/138=3.62x10(-4)): F5 rs6025 (p = 1.87x10(-5), SI = 1.29: previously observed) and F11 rs2036914 (p = 2.0x10(-4), SI = 0.91; new observation). CONCLUSIONS: The candidate-variant approach to identify supra-multiplicative associations between genetic variation and OC-HT use identified a new association with common genetic variation in F11 while the agnostic interrogations did not yield new discoveries. | |
dc.language.iso | EN | en_US |
dc.subject.en | Epidemiology | |
dc.subject.en | Gene-Environment Interaction | |
dc.subject.en | Hormone Replacement Therapy | |
dc.subject.en | Oral Contraceptives | |
dc.subject.en | Venous Thromboembolism | |
dc.title.en | Genome-Wide Investigation of Exogenous Female Hormones, Genetic Variation, and Venous Thromboembolism Risk | |
dc.title.alternative | J Thromb Haemost | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.jtha.2024.05.011 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
dc.identifier.pubmed | 38782299 | en_US |
bordeaux.journal | Journal of Thrombosis and Haemostasis | en_US |
bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.team | ELEANOR_BPH | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-04626937 | |
hal.version | 1 | |
hal.date.transferred | 2024-06-27T08:56:14Z | |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Thrombosis%20and%20Haemostasis&rft.date=2024-05-21&rft.eissn=1538-7836&rft.issn=1538-7836&rft.au=HASSER,%20Emily%20K&BRODY,%20Jennifer%20A&BARTZ,%20Traci%20M&THIBORD,%20Florian&LI-GAO,%20Ruifang&rft.genre=article |
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