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Increased risk of renal events in people with diabetic foot disease: A longitudinal observational study

dc.rights.licenseopenen_US
dc.contributor.authorALKHAMI, Fadi
dc.contributor.authorRUBIN, Sebastien
dc.contributor.authorBORDERIE, Gauthier
dc.contributor.authorFOUSSARD, Ninon
dc.contributor.authorLARROUMET, Alice
dc.contributor.authorBLANCO, Laurence
dc.contributor.authorBARBET-MASSIN, Marie-Amelie
dc.contributor.authorDOMENGE, Frederic
dc.contributor.authorMOHAMMEDI, Kamel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
dc.date.accessioned2024-06-26T12:28:48Z
dc.date.available2024-06-26T12:28:48Z
dc.date.issued2024-05-01
dc.identifier.issn1878-1780en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200658
dc.description.abstractEnOBJECTIVE: Diabetic kidney disease favors diabetic foot ulcers, however we do not know whether the reverse relation exists. We investigated whether diabetic foot disease (DFD) related to an increased risk of developing renal events. RESEARCH DESIGN AND METHODS: We conducted a retrospective analysis of a cohort of patients hospitalized for type 2 diabetes mellitus (T2DM) between 2009 and 2017, stratified for the risk of diabetic foot ulcer grades 0 (no risk), 1 and 2 (at risk), and 3 (DFD) according to the International Work Group on Diabetic Foot (IWGDF) classification. We highlighted new renal events (end-stage renal disease or a doubling of serum creatinine) in their medical records until December 2020. The relationship between DFD and later renal events was analyzed by multivariable Cox regression model. RESULTS: Among 519 patients, 142 (27 %) had a DFD at baseline, and 159 (30 %) were classified as Grades 1 or 2. Thirty-six renal events occurred during the 54 ± 27 months of follow-up: 19 subjects started dialysis, 1 had a renal transplantation, and 16 had a doubling of serum creatinine: 15 each in subjects with DFD and subjects at risk, versus 6 in subjects with Grade 0 DFD (logrank: P = 0.001). Adjusted for i) age and sex; ii) hyperglycemic exposure; iii) conventional cardiovascular risk factors; iv) renal parameters: and v) new diabetic foot ulcers during follow-up, DFD (HR 2.7 to 5.9) and being at risk of DFD Grades 1-2 (HR 2.8 to 5.1) were significantly related to new renal events. CONCLUSION: The risk of renal events was increased in people with T2DM and DFD.
dc.language.isoENen_US
dc.subject.enDiabetic foot disease
dc.subject.enRenal events
dc.subject.enType 2 diabetes
dc.title.enIncreased risk of renal events in people with diabetic foot disease: A longitudinal observational study
dc.title.alternativeDiabetes Metaben_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.diabet.2024.101536en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38701944en_US
bordeaux.journalDiabetes & Metabolismen_US
bordeaux.page101536en_US
bordeaux.volume50en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04625925
hal.version1
hal.date.transferred2024-06-26T12:28:50Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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