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Trends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration

dc.rights.licenseopenen_US
dc.contributor.authorTUSCH, Erich
dc.contributor.authorRYOM, Lene
dc.contributor.authorPELCHEN-MATTHEWS, Annegret
dc.contributor.authorMOCROFT, Amanda
dc.contributor.authorELBIRT, Daniel
dc.contributor.authorOPREA, Cristiana
dc.contributor.authorGUNTHARD, Huldrych F
dc.contributor.authorSTAEHELIN, Cornelia
dc.contributor.authorZANGERLE, Robert
dc.contributor.authorSUAREZ, Isabelle
dc.contributor.authorVEHRESCHILD, Jorg Janne
dc.contributor.authorWIT, Ferdinand
dc.contributor.authorMENOZZI, Marianna
dc.contributor.authorD'ARMINIO MONFORTE, Antonella
dc.contributor.authorSPAGNUOLO, Vincenzo
dc.contributor.authorPRADIER, Christian
dc.contributor.authorCARLANDER, Christina
dc.contributor.authorSUANZES, Paula
dc.contributor.authorWASMUTH, Jan-Christian
dc.contributor.authorCARR, Andrew
dc.contributor.authorPETOUMENOS, Kathy
dc.contributor.authorBORGANS, Frauke
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorBONNET, Fabrice
dc.contributor.authorDE WIT, Stephane
dc.contributor.authorEL-SADR, Wafaa
dc.contributor.authorNEESGAARD, Bastian
dc.contributor.authorJASCHINSKI, Nadine
dc.contributor.authorGREENBERG, Lauren
dc.contributor.authorHOSEIN, Sean R
dc.contributor.authorGALLANT, Joel
dc.contributor.authorVANNAPPAGARI, Vani
dc.contributor.authorYOUNG, Lital
dc.contributor.authorSABIN, Caroline
dc.contributor.authorLUNDGREN, Jens
dc.contributor.authorPETERS, Lars
dc.contributor.authorREEKIE, Joanne
dc.contributor.authorSTUDY, D. A. D. Cohort
dc.contributor.authorSTUDY, Respond Cohort
dc.date.accessioned2024-06-24T09:39:59Z
dc.date.available2024-06-24T09:39:59Z
dc.date.issued2024-04-26
dc.identifier.issn1058-4838en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200628
dc.description.abstractEnBACKGROUND: Mortality among people with HIV declined with the introduction of combination antiretroviral therapy. We investigated trends over time in all-cause and cause-specific mortality in people with HIV from 1999-2020. METHODS: Data were collected from the D:A:D cohort from 1999 through January 2015 and RESPOND from October 2017 through 2020. Age-standardized all-cause and cause-specific mortality rates, classified using Coding Causes of Death in HIV (CoDe), were calculated. Poisson regression models were used to assess mortality trends over time. RESULTS: Among 55716 participants followed for a median of 6 years (IQR 3-11), 5263 participants died (crude mortality rate [MR] 13.7/1000 PYFU; 95%CI 13.4-14.1). Changing patterns of mortality were observed with AIDS as the most common cause of death between 1999- 2009 (n = 952, MR 4.2/1000 PYFU; 95%CI 4.0-4.5) and non-AIDS defining malignancy (NADM) from 2010 -2020 (n = 444, MR 2.8/1000 PYFU; 95%CI 2.5-3.1). In multivariable analysis, all-cause mortality declined over time (adjusted mortality rate ratio [aMRR] 0.97 per year; 95%CI 0.96, 0.98), mostly from 1999 through 2010 (aMRR 0.96 per year; 95%CI 0.95-0.97), and with no decline shown from 2011 through 2020 (aMRR 1·00 per year; 95%CI 0·96-1·05). Mortality due all known causes except NADM also declined over the entire follow-up period. CONCLUSION: Mortality among people with HIV in the D:A:D and/or RESPOND cohorts decreased between 1999 and 2009 and was stable over the period from 2010 through 2020. The decline in mortality rates was not fully explained by improvements in immunologic-virologic status or other risk factors.
dc.language.isoENen_US
dc.subject.enHIV
dc.subject.enCohort Collaboration
dc.subject.enMortality
dc.subject.enObservational Cohort
dc.subject.enPeople With HIV
dc.title.enTrends in mortality in people with HIV from 1999 to 2020: a multi-cohort collaboration
dc.title.alternativeClin Infect Disen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cid/ciae228en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38663013en_US
bordeaux.journalClinical Infectious Diseasesen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut de Recherche pour le Développementen_US
hal.identifierhal-04621872
hal.version1
hal.date.transferred2024-06-24T09:40:04Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Clinical%20Infectious%20Diseases&rft.date=2024-04-26&rft.eissn=1058-4838&rft.issn=1058-4838&rft.au=TUSCH,%20Erich&RYOM,%20Lene&PELCHEN-MATTHEWS,%20Annegret&MOCROFT,%20Amanda&ELBIRT,%20Daniel&rft.genre=article


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