Early Mortality, Cardiovascular, and Renal Diseases in Women's Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION
| dc.rights.license | open | en_US |
| dc.contributor.author | LAILLER, Gregory | |
| dc.contributor.author | GRAVE, Clemence | |
| dc.contributor.author | GABET, Amelie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | JOLY, Pierre | |
| dc.contributor.author | REGNAULT, Nolwenn | |
| dc.contributor.author | DENEUX-THARAUX, Catherine | |
| dc.contributor.author | TSTSARIS, Vassilis | |
| dc.contributor.author | PLU-BUREAU, Genevieve | |
| dc.contributor.author | KRETZ, Sandrine | |
| dc.contributor.author | BLACHER, Jacques | |
| dc.contributor.author | OLIE, Valerie | |
| dc.date.accessioned | 2024-06-21T09:20:11Z | |
| dc.date.available | 2024-06-21T09:20:11Z | |
| dc.date.issued | 2024-04-16 | |
| dc.identifier.issn | 2047-9980 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200605 | |
| dc.description.abstractEn | BACKGROUND: We aimed to evaluate the impact of hypertensive disorders of pregnancy occurrence, recurrence, onset time, and severity on mortality and on a wide range of cardiovascular outcomes in France. METHODS AND RESULTS: CONCEPTION (Cohort of Cardiovascular Diseases in Pregnancy) is a French nationwide prospective cohort using data from the National Health Data System. We included all women in CONCEPTION with no history of a cardiovascular event who delivered in France for the first time between 2010 and 2018 (N=2 819 655). Hypertensive disorders of pregnancy and cardiovascular outcomes during the study follow-up were identified using algorithms combining International Classification of Diseases, Tenth Revision (ICD-10) coded diagnoses during hospitalization and purchases of medication between 2010 and 2021. We fitted Cox models with time-varying exposure to assess the associations of hypertensive disorders of pregnancy with mortality and cardiovascular events. Women with gestational hypertension had a 1.25- to 2-fold higher risk of stroke, acute coronary syndrome, peripheral arterial disease, pulmonary embolism, and chronic kidney disease, and a 2- to 4-fold higher risk of rhythm and conduction disorder and heart failure. Women with preeclampsia had a 1.35- to 2-fold higher risk of rhythm or conduction disorder and pulmonary embolism during follow-up; a 2- to 4-fold higher risk of stroke, acute coronary syndrome, and peripheral arterial disease; and a 7- to 9-fold higher risk of heart failure and chronic kidney disease. They were 1.8 times more likely to die and 4.4 times more likely to die of cardiovascular causes. CONCLUSIONS: Hypertensive disorders of pregnancy drastically increase the risk of mortality, cardiovascular, and renal events early after pregnancy. Recurrent, severe, and early-onset preeclampsia further increases this risk. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Cardiovascular Diseases | |
| dc.subject.en | Cardiovascular Risk Factors | |
| dc.subject.en | Epidemiology | |
| dc.subject.en | Gestational Hypertension | |
| dc.subject.en | Hypertensive Disorders Of Pregnancy | |
| dc.subject.en | Preeclampsia | |
| dc.title.en | Early Mortality, Cardiovascular, and Renal Diseases in Women's Lives Following Hypertensive Disorders of Pregnancy: The Prospective Nationwide Study CONCEPTION | |
| dc.title.alternative | J Am Heart Assoc | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1161/jaha.123.033252 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38563390 | en_US |
| bordeaux.journal | Journal of the American Heart Association | en_US |
| bordeaux.page | e033252 | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 8 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Société Française d’Hypertension Artérielle | en_US |
| bordeaux.identifier.funderID | Fédération Française de Cardiologie | en_US |
| hal.identifier | hal-04619977 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-06-21T09:20:13Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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