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Frailty Influences the Relationship between the Soluble Receptor for Advanced Glycation-End Products and Mortality in Older Adults with Diabetes Mellitus

dc.rights.licenseopenen_US
dc.contributor.authorBUTCHER, Lee
dc.contributor.authorCARNICERO, Jose A
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPERES, Karine
ORCID: 0000-0002-0720-0684
IDREF: 080634001
dc.contributor.authorBANDINELLI, Stefania
dc.contributor.authorGARCIA-GARCIA, Francisco Jose
dc.contributor.authorRODRIGUEZ-ARTALEJO, Fernando
dc.contributor.authorRODRIGUEZ-MANAS, Leocadio
dc.contributor.authorERUSALIMSKY, Jorge D
dc.date.accessioned2024-06-17T09:45:43Z
dc.date.available2024-06-17T09:45:43Z
dc.date.issued2024-06-01
dc.identifier.issn1423-0003 (Electronic) 0304-324X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200488
dc.description.abstractEnINTRODUCTION: Frailty is prevalent among older adults with diabetes mellitus. Elevated serum levels of the soluble receptor for advanced glycation-end products (sRAGE) predict mortality in frail older adults. The evidence that sRAGE is also related to higher mortality in older adults with diabetes mellitus is inconsistent. Therefore, this study explored if frailty status influences the relationship between sRAGE and mortality in older adults with this condition. METHODS: We analysed data of 391 participants with diabetes mellitus (median age, 76 years) from four European cohorts enrolled in the FRAILOMIC project. Frailty was evaluated at baseline using Fried's criteria. Serum sRAGE was determined by ELISA. Participants were stratified by frailty status (n = 280 non-frail and 111 frail). Multivariate Cox proportional hazards regression and Kaplan-Meier survival analysis were used to assess the relationship between sRAGE and mortality. RESULTS: During 6 years of follow-up, 98 participants died (46 non-frail and 52 frail). Non-survivors had significantly higher baseline levels of sRAGE than survivors (median [IQR]: 1,392 [962-2,043] pg/mL vs. 1,212 [963-1,514], p = 0.008). High serum sRAGE (>1,617 pg/mL) was associated with increased mortality in the whole diabetes sample after adjustment for relevant confounders (HR 2.06, 95% CI: 1.36-3.11, p < 0.001), and there was an interaction between sRAGE and frailty (p = 0.006). Accordingly, the association between sRAGE and mortality was stronger in the frail group compared to the non-frail group (HR 2.52, 95% CI: 1.30-4.90, p = 0.006 vs. HR 1.71, 95% CI: 0.91-3.23, p = 0.099, respectively). Likewise, Kaplan-Meier curves showed a significant difference in survival rates between frail participants with high sRAGE and those with low sRAGE (p = 0.001), whereas no survival difference was seen in the non-frail group (p = 0.09). CONCLUSIONS: Frailty status influences the relationship between sRAGE and mortality in older adults with diabetes mellitus. Determination of sRAGE in this population could be a useful tool for risk stratification.
dc.language.isoENen_US
dc.subject.enBiomarker
dc.subject.enDiabetes
dc.subject.enFrailty
dc.subject.enMortality
dc.subject.enRAGE
dc.title.enFrailty Influences the Relationship between the Soluble Receptor for Advanced Glycation-End Products and Mortality in Older Adults with Diabetes Mellitus
dc.title.alternativeGerontologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1159/000538292en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38593754en_US
bordeaux.journalGerontologyen_US
bordeaux.page585-594en_US
bordeaux.volume70en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue6en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamACTIVE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04614076
hal.version1
hal.date.transferred2024-06-17T09:45:45Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Gerontology&rft.date=2024-06-01&rft.volume=70&rft.issue=6&rft.spage=585-594&rft.epage=585-594&rft.eissn=1423-0003%20(Electronic)%200304-324X%20(Linking)&rft.issn=1423-0003%20(Electronic)%200304-324X%20(Linking)&rft.au=BUTCHER,%20Lee&CARNICERO,%20Jose%20A&PERES,%20Karine&BANDINELLI,%20Stefania&GARCIA-GARCIA,%20Francisco%20Jose&rft.genre=article


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