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Prediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBERCU, Ariane
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDUFOUIL, Carole
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorJOLIOT, Marc
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTSUCHIDA, Ami
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEVAUX, Anthony
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUTELOUP, Vincent
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X
IDREF: 114375747
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJACQMIN-GADDA, Helene
dc.date.accessioned2024-06-17T08:18:44Z
dc.date.available2024-06-17T08:18:44Z
dc.date.issued2024-04-01
dc.identifier.issn2352-8729en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200486
dc.description.abstractEnABSTRACT: The utility of brain magnetic resonance imaging (MRI) for predicting dementia is debated. We evaluated the added value of repeated brain MRI, including atrophy and cerebral small vessel disease markers, for dementia prediction. We conducted a landmark competing risk analysis in 1716 participants of the French population-based Three-City Study to predict the 5-year risk of dementia using repeated measures of 41 predictors till year 4 of follow-up. Brain MRI markers improved significantly the individual prediction of dementia after accounting for demographics, health measures, and repeated measures of cognition and functional dependency (area under the ROC curve [95% CI] improved from 0.80 [0.79 to 0.82] to 0.83 [0.81 to 0.84]). Nonetheless, accounting for the change over time through repeated MRIs had little impact on predictive abilities. These results highlight the importance of multimodal analysis to evaluate the added predictive abilities of repeated brain MRI for dementia and offer new insights into the predictive performances of various MRI markers. HIGHLIGHTS: We evaluated whether repeated brain volumes and cSVD markers improve dementia prediction.The 5-year prediction of dementia is slightly improved when considering brain MRI markers.Measures of hippocampus volume are the main MRI predictors of dementia.Adjusted on cognition, repeated MRI has poor added value over single MRI for dementia prediction.We utilized a longitudinal analysis that considers error-and-missing-prone predictors, and competing death.
dc.description.sponsorshipAge, sommeil et processus cognitifsen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enBrain Volume
dc.subject.enCognition
dc.subject.enCompeting Risks
dc.subject.enDementia
dc.subject.enHippocampal Volume
dc.subject.enLandmark
dc.subject.enMixed Model
dc.subject.enSurvival
dc.subject.enWhite Matter Hyperintensities
dc.title.enPrediction of dementia risk from multimodal repeated measures: The added value of brain MRI biomarkers
dc.title.alternativeAlzheimers Dement (Amst)en_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/dad2.12578en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed38800122en_US
bordeaux.journalAlzheimer's & dementiaen_US
bordeaux.pagee12578en_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamLEHA_BPHen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.teamPHARES_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDSanofien_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDMutuelle Générale de l'Education Nationaleen_US
bordeaux.identifier.funderIDFondation de Franceen_US
bordeaux.identifier.funderIDFondation Plan Alzheimeren_US
bordeaux.identifier.funderIDCaisse nationale de solidarité pour l'autonomieen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
hal.identifierhal-04613846
hal.version1
hal.date.transferred2024-06-17T08:18:48Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Alzheimer's%20&%20dementia&rft.date=2024-04-01&rft.volume=16&rft.issue=2&rft.spage=e12578&rft.epage=e12578&rft.eissn=2352-8729&rft.issn=2352-8729&rft.au=BERCU,%20Ariane&DUFOUIL,%20Carole&DEBETTE,%20Stephanie&JOLIOT,%20Marc&TSUCHIDA,%20Ami&rft.genre=article


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