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Volumetric changes and clinical trajectories in Parkinson’s disease: a prospective multicentric study

dc.rights.licenseopenen_US
dc.contributor.authorMARQUES, Ana
dc.contributor.authorMACIAS, Elise
dc.contributor.authorPEREIRA, Bruno
dc.contributor.authorDURAND, Elodie
dc.contributor.authorCHASSAIN, Carine
dc.contributor.authorVIDAL, Tiphaine
dc.contributor.authorDEFEBVRE, Luc
dc.contributor.authorCARRIERE, Nicolas
dc.contributor.authorFRAIX, Valerie
dc.contributor.authorMORO, Elena
dc.contributor.authorTHOBOIS, Stephane
dc.contributor.authorMETEREAU, Elise
dc.contributor.authorMANGONE, Graziella
dc.contributor.authorVIDAILHET, Marie
dc.contributor.authorCORVOL, Jean-Christophe
dc.contributor.authorLEHERICY, Stephane
dc.contributor.authorMENJOT DE CHAMPFLEUR, Nicolas
dc.contributor.authorGENY, Christian
hal.structure.identifierInstitut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA]
dc.contributor.authorSPAMPINATO, Umberto
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMEISSNER, Wassilios
dc.contributor.authorFRISMAND, Solene
dc.contributor.authorSCHMITT, Emmanuelle
dc.contributor.authorDOE DE MAINDREVILLE, Anne
dc.contributor.authorPORTEFAIX, Christophe
dc.contributor.authorREMY, Philippe
dc.contributor.authorFENELON, Gilles
dc.contributor.authorHOUETO, Jean-Luc
dc.contributor.authorCOLIN, Olivier
dc.contributor.authorRASCOL, Olivier
dc.contributor.authorPERAN, Patrice
dc.contributor.authorBONNY, Jean-Marie
dc.contributor.authorFANTINI, Maria Livia
dc.contributor.authorDURIF, Franck
dc.date.accessioned2024-06-10T12:06:36Z
dc.date.available2024-06-10T12:06:36Z
dc.date.issued2023-08-31
dc.identifier.issn0340-5354en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200372
dc.description.abstractEnBackground: Longitudinal measures of structural brain changes using MRI in relation to clinical features and progression patterns in PD have been assessed in previous studies, but few were conducted in well-defined and large cohorts, including prospective clinical assessments of both motor and non-motor symptoms. Objective: We aimed to identify brain volumetric changes characterizing PD patients, and determine whether regional brain volumetric characteristics at baseline can predict motor, psycho-behavioral and cognitive evolution at one year in a prospective cohort of PD patients. Methods: In this multicentric 1 year longitudinal study, PD patients and healthy controls from the MPI-R2* cohort were assessed for demographical, clinical and brain volumetric characteristics. Distinct subgroups of PD patients according to motor, cognitive and psycho-behavioral evolution were identified at the end of follow-up. Results: One hundred and fifty PD patients and 73 control subjects were included in our analysis. Over one year, there was no significant difference in volume variations between PD and control subjects, regardless of the brain region considered. However, we observed a reduction in posterior cingulate cortex volume at baseline in PD patients with motor deterioration at one year (p = 0.017). We also observed a bilateral reduction of the volume of the amygdala (p = 0.015 and p = 0.041) and hippocampus (p = 0.015 and p = 0.053) at baseline in patients with psycho-behavioral deterioration, regardless of age, dopaminergic treatment and center. Conclusion: Brain volumetric characteristics at baseline may predict clinical trajectories at 1 year in PD as posterior cingulate cortex atrophy was associated with motor decline, while amygdala and hippocampus atrophy were associated with psycho-behavioral decline.
dc.language.isoENen_US
dc.subject.enBrain atrophy
dc.subject.enClinical progression
dc.subject.enLongitudinal study
dc.subject.enParkinson’s disease
dc.subject.enVolumetric changes
dc.title.enVolumetric changes and clinical trajectories in Parkinson’s disease: a prospective multicentric study
dc.title.alternativeJ Neurolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s00415-023-11947-0en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed37648911en_US
bordeaux.journalJournal of Neurologyen_US
bordeaux.page6033-6043en_US
bordeaux.volume270en_US
bordeaux.hal.laboratoriesInstitut de neurosciences cognitives et intégratives d'Aquitaine (INCIA) - UMR 5287en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAssociation France Parkinsonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
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