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dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPANNETIER, Pauline
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMORIN, Benedicte
IDREF: 178000892
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCLERANDEAU, Christelle
dc.contributor.authorLACROIX, Camille
dc.contributor.authorCABON, Joëlle
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorCACHOT, Jérôme
ORCID: 0000-0002-1492-9684
IDREF: 19667672X
dc.contributor.authorDANION, Morgane
dc.date.accessioned2024-06-06T09:00:27Z
dc.date.available2024-06-06T09:00:27Z
dc.date.issued2019-02-20
dc.identifier.issn1879-1026en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200301
dc.description.abstractEnIt is now well documented that several contaminants can modulate the fish immune system, leading to disrupted host resistance against pathogens and increased incidence of disease. Since fish are usually co-exposed to chemicals and pathogens in the natural environment, analysis of the immunotoxic effects of pollutants is particularly relevant. The authorities in the European Union have recommended the development of toxicity assays on cell cultures and embryos, as an alternative to testing in vertebrates. This is why in our study, a fish immune challenge assay was developed for the early life stages of Japanese medaka to evaluate and compare the relevance of new biomarkers. Fish were exposed to benzo[a]pyrene (BaP), a model pollutant, for 8days at the embryonic stage, or for 48h at the larvae and juvenile stages, and fish were infected with betanodavirus by bath-challenge of 10TCID/mL. Biometric changes and induction of malformations were observed after embryonic exposure. DNA damage and induction of EROD activity were recorded at the end of all chemical exposures. Viral infection increased the mortality rate significantly and disturbed the behavior of fish after light stimulation. While BaP exposure increased swimming speed, betanodavirus infection slowed swimming activity. In larvae co-exposed to BaP and the virus, the viral titer in the whole body was higher than in fish infected only with the virus. This study highlighted the sensitivity and usefulness of the immune challenge assay on the early life stages of Japanese medaka to evaluate the toxic effects of pollutants.
dc.language.isoENen_US
dc.subject.enAnimals
dc.subject.enBenzo(a)pyrene
dc.subject.enBiomarkers
dc.subject.enEmbryo
dc.subject.enNonmammalian
dc.subject.enNodaviridae
dc.subject.enOryzias
dc.subject.enWater Pollutants
dc.subject.enChemical
dc.title.enComparative biomarker responses in Japanese medaka (Oryzias latipes) exposed to benzo[a]pyrene and challenged with betanodavirus at three different life stages.
dc.title.alternativeSci Total Environen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.scitotenv.2018.10.256en_US
dc.subject.halSciences de l'environnementen_US
dc.identifier.pubmed30380501en_US
bordeaux.journalScience of the Total Environmenten_US
bordeaux.page964-976en_US
bordeaux.volume652en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.identifierhal-04603121
hal.version1
hal.date.transferred2024-06-06T09:00:29Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20of%20the%20Total%20Environment&rft.date=2019-02-20&rft.volume=652&rft.spage=964-976&rft.epage=964-976&rft.eissn=1879-1026&rft.issn=1879-1026&rft.au=PANNETIER,%20Pauline&MORIN,%20Benedicte&CLERANDEAU,%20Christelle&LACROIX,%20Camille&CABON,%20Jo%C3%ABlle&rft.genre=article


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