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Comparative biomarker responses in Japanese medaka (Oryzias latipes) exposed to benzo[a]pyrene and challenged with betanodavirus at three different life stages.
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | PANNETIER, Pauline | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | MORIN, Benedicte
IDREF: 178000892 | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | CLERANDEAU, Christelle | |
| dc.contributor.author | LACROIX, Camille | |
| dc.contributor.author | CABON, Joëlle | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | CACHOT, Jérôme
ORCID: 0000-0002-1492-9684 IDREF: 19667672X | |
| dc.contributor.author | DANION, Morgane | |
| dc.date.accessioned | 2024-06-06T09:00:27Z | |
| dc.date.available | 2024-06-06T09:00:27Z | |
| dc.date.issued | 2019-02-20 | |
| dc.identifier.issn | 1879-1026 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200301 | |
| dc.description.abstractEn | It is now well documented that several contaminants can modulate the fish immune system, leading to disrupted host resistance against pathogens and increased incidence of disease. Since fish are usually co-exposed to chemicals and pathogens in the natural environment, analysis of the immunotoxic effects of pollutants is particularly relevant. The authorities in the European Union have recommended the development of toxicity assays on cell cultures and embryos, as an alternative to testing in vertebrates. This is why in our study, a fish immune challenge assay was developed for the early life stages of Japanese medaka to evaluate and compare the relevance of new biomarkers. Fish were exposed to benzo[a]pyrene (BaP), a model pollutant, for 8days at the embryonic stage, or for 48h at the larvae and juvenile stages, and fish were infected with betanodavirus by bath-challenge of 10TCID/mL. Biometric changes and induction of malformations were observed after embryonic exposure. DNA damage and induction of EROD activity were recorded at the end of all chemical exposures. Viral infection increased the mortality rate significantly and disturbed the behavior of fish after light stimulation. While BaP exposure increased swimming speed, betanodavirus infection slowed swimming activity. In larvae co-exposed to BaP and the virus, the viral titer in the whole body was higher than in fish infected only with the virus. This study highlighted the sensitivity and usefulness of the immune challenge assay on the early life stages of Japanese medaka to evaluate the toxic effects of pollutants. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Animals | |
| dc.subject.en | Benzo(a)pyrene | |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Embryo | |
| dc.subject.en | Nonmammalian | |
| dc.subject.en | Nodaviridae | |
| dc.subject.en | Oryzias | |
| dc.subject.en | Water Pollutants | |
| dc.subject.en | Chemical | |
| dc.title.en | Comparative biomarker responses in Japanese medaka (Oryzias latipes) exposed to benzo[a]pyrene and challenged with betanodavirus at three different life stages. | |
| dc.title.alternative | Sci Total Environ | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.scitotenv.2018.10.256 | en_US |
| dc.subject.hal | Sciences de l'environnement | en_US |
| dc.identifier.pubmed | 30380501 | en_US |
| bordeaux.journal | Science of the Total Environment | en_US |
| bordeaux.page | 964-976 | en_US |
| bordeaux.volume | 652 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | EA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | pubmed | |
| hal.identifier | hal-04603121 | |
| hal.version | 1 | |
| hal.date.transferred | 2024-06-06T09:00:29Z | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | true | |
| workflow.import.source | pubmed | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Science%20of%20the%20Total%20Environment&rft.date=2019-02-20&rft.volume=652&rft.spage=964-976&rft.epage=964-976&rft.eissn=1879-1026&rft.issn=1879-1026&rft.au=PANNETIER,%20Pauline&MORIN,%20Benedicte&CLERANDEAU,%20Christelle&LACROIX,%20Camille&CABON,%20Jo%C3%ABlle&rft.genre=article |
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