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Influenza and Pneumococcal vaccination effects on the immune-related adverse events in patients under immunotherapy for an advanced stage non-small cell lung cancer

dc.rights.licenseopenen_US
dc.contributor.authorMONBRUN, Mathilde
dc.contributor.authorGRASSION, Léo
dc.contributor.authorBLANCHARD, Elodie
dc.contributor.authorVEILLON, Rémi
dc.contributor.authorZYSMAN, Maeva
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.date.accessioned2024-05-28T13:58:44Z
dc.date.available2024-05-28T13:58:44Z
dc.date.issued2021-09-05
dc.date.conference2021-09-05
dc.identifier.issn0169-5002en_US
dc.identifier.urioai:crossref.org:10.1183/13993003.congress-2021.pa2303
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200101
dc.description.abstractEnIntroduction: Patients with non-small cell lung cancer (NSCLC) are at high risk of severe influenza and invasive pneumococcal infections. Literature data on the effect of influenza vaccination on the incidence of immune-related Adverse Events (irAEs) under immunotherapy are contradictory (Wijn. D.H. et al, Eur J Cancer. Nov 2018;104:182-7), (Läubli. H., et al, J Immunother Cancer 2018;6(1):40) and there are no data on the effect of pneumococcal vaccination. Aims and objectives: Our objective is therefore to study the effect of influenza and pneumococcal vaccination on the incidence of irAEs in patients receiving immunotherapy for advanced stage NSCLC. Methods: Patients included began immunotherapy between August, 2018 and April, 2019 at the Bordeaux University Hospital. Vaccination status for influenza and pneumococcus was collected retrospectively, as was the occurrence of irAEs within 6 months, grade of severity, onset time and type of irAEs. Of the 80 patients included in the study, 31 were not vaccinated, 36 were vaccinated for influenza and pneumococcus and 13 had pneumococcal vaccine or influenza vaccine only. The overall incidence of irAEs was 25.0%. For double vaccinated patients it was 19.4% and 29.0% for unvaccinated patients (p = 0.401). The majority of irAEs were mild (88.0%) and occurred early. The incidence of irAEs in patients receiving immunotherapy for advanced NSCLC has not increased when patients were vaccinated for influenza and pneumococcus
dc.language.isoENen_US
dc.publisherEuropean Respiratory Societyen_US
dc.sourcecrossref
dc.subject.enLung cancer
dc.subject.enVaccination
dc.title.enInfluenza and Pneumococcal vaccination effects on the immune-related adverse events in patients under immunotherapy for an advanced stage non-small cell lung cancer
dc.typeCommunication dans un congrèsen_US
dc.identifier.doi10.1183/13993003.congress-2021.pa2303en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
bordeaux.pagePA2303en_US
bordeaux.volume58en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issuesuppl. 65en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.conference.title2021 ERS International Congressen_US
bordeaux.title.proceedingEuropean Respiratory Journalen_US
bordeaux.teamEPICENE_BPHen_US
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hal.proceedingsouien_US
hal.conference.organizerEuropean Respiratory Society (ERS)en_US
hal.conference.end2021-09-08
hal.popularnonen_US
hal.audienceInternationaleen_US
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dc.rights.ccPas de Licence CCen_US
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