Higher Risk of Mortality in HIV-HBV Co-Infected Patients from Sub-Saharan Africa Is Observed at Lower CD4 \textsuperscript+ Cell Counts
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | KOUAME, Menan Gerard | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GABILLARD, Delphine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOH, Raoul | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BADJE, Anani | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | N'TAKPE, Jean-Baptiste | |
| hal.structure.identifier | Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] [CeDreS] | |
| dc.contributor.author | EMIÈME, Arlette | |
| hal.structure.identifier | Hopital Saint-Louis [AP-HP] [AP-HP] | |
| dc.contributor.author | MAYLIN, Sarah | |
| hal.structure.identifier | Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] [CeDreS] | |
| dc.contributor.author | TONI, Thomas | |
| hal.structure.identifier | Centre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] [CeDreS] | |
| dc.contributor.author | MÉNAN, Hervé | |
| hal.structure.identifier | Centre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL] | |
| dc.contributor.author | ZOULIM, Fabien | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DANEL, Christine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ANGLARET, Xavier | |
| hal.structure.identifier | Centre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] [CHU de Treichville] | |
| hal.structure.identifier | Programme PAC-CI | |
| dc.contributor.author | EHOLIÉ, Serge | |
| hal.structure.identifier | Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP] | |
| hal.structure.identifier | CHU Saint-Antoine [AP-HP] | |
| dc.contributor.author | LACOMBE, Karine | |
| hal.structure.identifier | Institut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP] | |
| dc.contributor.author | BOYD, Anders | |
| dc.date.accessioned | 2024-05-27T14:56:59Z | |
| dc.date.available | 2024-05-27T14:56:59Z | |
| dc.date.issued | 2021-01-01 | |
| dc.identifier.issn | 2040-2058 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/200083 | |
| dc.description.abstractEn | Background Hepatitis B virus (HBV) co-infection in human immunodeficiency virus (HIV)-positive individuals increases the risk of overall mortality, especially when HBV DNA levels are high. The role of CD4 + cell counts in this association is poorly defined. We aimed to determine whether HIV\textendash HBV co-infection influences changes in CD4 + cell count before and during antiretroviral therapy and whether it affects mortality risk at levels of CD4 + . Methods 2052 HIV-positive participants from Côte d'Ivoire in a randomized-control trial assessing early or deferred ART were included. HBV-status was determined by hepatitis B surface antigen (HBsAg). Changes in CD4 + cell levels were estimated using a mixed-effect linear model. The incidence rates of all-cause mortality were estimated at CD4 + counts ≤q350, 351\textendash 500, >500/mm 3 and were compared between HBV-status groups as incidence rate ratios (IRR). Results At baseline, 190 (9%) were HBsAg-positive [135 (71%) with HBV DNA 500/mm 3 (adjusted-IRR = 1.07, 95% CI = 0.01\textendash 4.91). Conclusion Despite no effect of HBV-infection on CD4 + levels, HIV-HBV co-infected individuals with high HBV replication are at higher risk of mortality when CD4 + is <500/mm 3 . | |
| dc.language.iso | EN | en_US |
| dc.title.en | Higher Risk of Mortality in HIV-HBV Co-Infected Patients from Sub-Saharan Africa Is Observed at Lower CD4 \textsuperscript+ Cell Counts | |
| dc.title.alternative | Antivir Ther | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1177/13596535211039589 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio] | en_US |
| dc.identifier.pubmed | 35485344 | en_US |
| bordeaux.journal | Antiviral Therapy | en_US |
| bordeaux.page | 25--33 | en_US |
| bordeaux.volume | 26 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 1-2 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | IDLIC_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Recherches sur le Sida et les Hépatites Virales | en_US |
| bordeaux.import.source | hal | |
| hal.identifier | hal-03777524 | |
| hal.version | 1 | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | hal | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Antiviral%20Therapy&rft.date=2021-01-01&rft.volume=26&rft.issue=1-2&rft.spage=25--33&rft.epage=25--33&rft.eissn=2040-2058&rft.issn=2040-2058&rft.au=KOUAME,%20Menan%20Gerard&GABILLARD,%20Delphine&MOH,%20Raoul&BADJE,%20Anani&N'TAKPE,%20Jean-Baptiste&rft.genre=article |
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