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dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorKOUAME, Menan Gerard
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGABILLARD, Delphine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMOH, Raoul
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBADJE, Anani
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorN'TAKPE, Jean-Baptiste
hal.structure.identifierCentre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] [CeDreS]
dc.contributor.authorEMIÈME, Arlette
hal.structure.identifierHopital Saint-Louis [AP-HP] [AP-HP]
dc.contributor.authorMAYLIN, Sarah
hal.structure.identifierCentre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] [CeDreS]
dc.contributor.authorTONI, Thomas
hal.structure.identifierCentre de recherche et de Diagnostic sur le Sida [Abidjan, Côte d'Ivoire] [CeDreS]
dc.contributor.authorMÉNAN, Hervé
hal.structure.identifierCentre de Recherche en Cancérologie de Lyon [UNICANCER/CRCL]
dc.contributor.authorZOULIM, Fabien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDANEL, Christine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorANGLARET, Xavier
hal.structure.identifierCentre Hospitalier Universitaire de Treichville [Abidjan, Côte d'Ivoire] [CHU de Treichville]
hal.structure.identifierProgramme PAC-CI
dc.contributor.authorEHOLIÉ, Serge
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
hal.structure.identifierCHU Saint-Antoine [AP-HP]
dc.contributor.authorLACOMBE, Karine
hal.structure.identifierInstitut Pierre Louis d'Epidémiologie et de Santé Publique [iPLESP]
dc.contributor.authorBOYD, Anders
dc.date.accessioned2024-05-27T14:56:59Z
dc.date.available2024-05-27T14:56:59Z
dc.date.issued2021-01-01
dc.identifier.issn2040-2058en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200083
dc.description.abstractEnBackground Hepatitis B virus (HBV) co-infection in human immunodeficiency virus (HIV)-positive individuals increases the risk of overall mortality, especially when HBV DNA levels are high. The role of CD4 + cell counts in this association is poorly defined. We aimed to determine whether HIV\textendash HBV co-infection influences changes in CD4 + cell count before and during antiretroviral therapy and whether it affects mortality risk at levels of CD4 + . Methods 2052 HIV-positive participants from Côte d'Ivoire in a randomized-control trial assessing early or deferred ART were included. HBV-status was determined by hepatitis B surface antigen (HBsAg). Changes in CD4 + cell levels were estimated using a mixed-effect linear model. The incidence rates of all-cause mortality were estimated at CD4 + counts ≤q350, 351\textendash 500, >500/mm 3 and were compared between HBV-status groups as incidence rate ratios (IRR). Results At baseline, 190 (9%) were HBsAg-positive [135 (71%) with HBV DNA 500/mm 3 (adjusted-IRR = 1.07, 95% CI = 0.01\textendash 4.91). Conclusion Despite no effect of HBV-infection on CD4 + levels, HIV-HBV co-infected individuals with high HBV replication are at higher risk of mortality when CD4 + is <500/mm 3 .
dc.language.isoENen_US
dc.title.enHigher Risk of Mortality in HIV-HBV Co-Infected Patients from Sub-Saharan Africa Is Observed at Lower CD4 \textsuperscript+ Cell Counts
dc.title.alternativeAntivir Theren_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1177/13596535211039589en_US
dc.subject.halSciences du Vivant [q-bio]en_US
dc.identifier.pubmed35485344en_US
bordeaux.journalAntiviral Therapyen_US
bordeaux.page25--33en_US
bordeaux.volume26en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue1-2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamIDLIC_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de Recherches sur le Sida et les Hépatites Viralesen_US
bordeaux.import.sourcehal
hal.identifierhal-03777524
hal.version1
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Antiviral%20Therapy&amp;rft.date=2021-01-01&amp;rft.volume=26&amp;rft.issue=1-2&amp;rft.spage=25--33&amp;rft.epage=25--33&amp;rft.eissn=2040-2058&amp;rft.issn=2040-2058&amp;rft.au=KOUAME,%20Menan%20Gerard&amp;GABILLARD,%20Delphine&amp;MOH,%20Raoul&amp;BADJE,%20Anani&amp;N'TAKPE,%20Jean-Baptiste&amp;rft.genre=article


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