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Multivalent and multifunctional polysaccharide-based particles for controlled receptor recognition

dc.rights.licenseopen
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorDUAN, Haohao
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
dc.contributor.authorDONOVAN, Mark
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
dc.contributor.authorFOUCHER, Aude
hal.structure.identifierL'Oréal Recherche France [L'Oréal Recherche]
dc.contributor.authorSCHULTZE, Xavier
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2018
dc.identifier.issn2045-2322
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/20003
dc.description.abstractEnPolysaccharides represent a versatile class of building blocks that are used in macromolecular design. By choosing the appropriate saccharide block, various physico-chemical and biological properties can be introduced both at the level of the polymer chains and the resulting self-assembled nanostructures. Here, we synthetized amphiphilic diblock copolymers combining a hydrophobic and helical poly(γ-benzyl-L-glutamate) PBLG and two polysaccharides, namely hyaluronic acid (HA) and laminarin (LAM). The copolymers could self-assemble to form particles in water by nanoprecipitation. In addition, hybrid particles containing both HA and LAM in different ratios were obtained by co-nanoprecipitation of the two copolymers. By controlling the self-assembly process, five particle samples with different morphologies and compositions were developed. The interaction between the particles and biologically relevant proteins for HA and LAM, namely CD44 and Dectin-1 respectively, was evaluated by surface plasmon resonance (SPR). We demonstrated that the particle-protein interaction could be modulated by the particle structure and composition. It is therefore suggested that this method based on nanoprecipitation is a practical and versatile way to obtain particles with controllable interactions with proteins, hence with the appropriate biological properties for biomedical applications such as drug delivery.
dc.language.isoen
dc.publisherNature Publishing Group
dc.rights.urihttp://creativecommons.org/licenses/by/
dc.title.enMultivalent and multifunctional polysaccharide-based particles for controlled receptor recognition
dc.typeArticle de revue
dc.identifier.doi10.1038/s41598-018-32994-y
dc.subject.halChimie/Polymères
dc.subject.halChimie/Chimie thérapeutique
bordeaux.journalScientific Reports
bordeaux.page14730
bordeaux.volume8
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01893210
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01893210v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Scientific%20Reports&rft.date=2018&rft.volume=8&rft.issue=1&rft.spage=14730&rft.epage=14730&rft.eissn=2045-2322&rft.issn=2045-2322&rft.au=DUAN,%20Haohao&DONOVAN,%20Mark&FOUCHER,%20Aude&SCHULTZE,%20Xavier&LECOMMANDOUX,%20Sebastien&rft.genre=article


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