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Tobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEVOS, Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, François
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHESSAMFAR, Mojgan
dc.contributor.authorNEAU, D.
dc.contributor.authorVAREIL, M.-O.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLELEUX, Olivier
dc.contributor.authorCAZANAVE, C.
dc.contributor.authorROUANES, N.
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDUFFAU, Pierre
dc.contributor.authorLAZARO, E.
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDABIS, Francois
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBARGER, Diana
dc.contributor.authorBELLECAVE, P.
dc.contributor.authorBLANCO, P.
dc.contributor.authorBOUCHET, S.
dc.contributor.authorBREILH, D.
dc.contributor.authorDESJARDIN, S.
dc.contributor.authorGABORIEAU, V.
dc.contributor.authorGIMBERT, A.
dc.contributor.authorLACAZE-BUZY, L.
dc.contributor.authorLACOSTE, D.
dc.contributor.authorLAFON, M.E.
dc.contributor.authorLAWSON-AYAYI, S.
dc.contributor.authorLE MAREC, F.
dc.contributor.authorLE MOAL, G.
dc.contributor.authorMALVY, Denis
dc.contributor.authorMARCHAND, L.
dc.contributor.authorMERCIÉ, P.
dc.contributor.authorPELLEGRIN, I.
dc.contributor.authorPERRIER, A.
dc.contributor.authorPETROV-SANCHEZ, V.
dc.contributor.authorBERNARD, N.
dc.contributor.authorBRONNIMANN, D.
dc.contributor.authorCHAUSSADE, H.
dc.contributor.authorDONDIA, D.
dc.contributor.authorFAURE, I.
dc.contributor.authorMORLAT, P.
dc.contributor.authorMÉRIGLIER, E.
dc.contributor.authorPACCALIN, F.
dc.contributor.authorRIEBERO, E.
dc.contributor.authorRIVOISY, C.
dc.contributor.authorVANDENHENDE, M.A.
dc.contributor.authorBARTHOD, L.
dc.contributor.authorDAUCHY, F.A.
dc.contributor.authorDESCLAUX, A.
dc.contributor.authorDUCOURS, M.
dc.contributor.authorDUTRONC, H.
dc.contributor.authorDUVIGNAUD, A.
dc.contributor.authorLEITAO, J.
dc.contributor.authorLESCURE, M.
dc.contributor.authorNGUYEN, D.
dc.contributor.authorPISTONE, T.
dc.contributor.authorPUGES, M.
dc.contributor.authorWIRTH, G.
dc.contributor.authorCOURTAULT, C.
dc.contributor.authorCAMOU, F.
dc.contributor.authorGREIB, C.
dc.contributor.authorPELLEGRIN, J.L.
dc.contributor.authorRIVIÈRE, E.
dc.contributor.authorVIALLARD, J.F.
dc.contributor.authorIMBERT, Y.
dc.contributor.authorTHIERRY-MIEG, M.
dc.contributor.authorRISPAL, P.
dc.contributor.authorCAUBET, O.
dc.contributor.authorFERRAND, H.
dc.contributor.authorTCHAMGOUÉ, S.
dc.contributor.authorFARBOS, S.
dc.contributor.authorWILLE, H.
dc.contributor.authorANDRE, K.
dc.contributor.authorCAUNEGRE, L.
dc.contributor.authorGERARD, Y.
dc.contributor.authorOSORIO-PEREZ, F.
dc.contributor.authorCHOSSAT, I.
dc.contributor.authorILES, G.
dc.contributor.authorLABASSE-DEPIS, M.
dc.contributor.authorLACASSIN, F.
dc.contributor.authorBARRET, A.
dc.contributor.authorCASTAN, B.
dc.contributor.authorKOFFI, J.
dc.contributor.authorSAUNIER, A.
dc.contributor.authorZABBE, J.B.
dc.contributor.authorDUMONDIN, G.
dc.contributor.authorBERAUD, G.
dc.contributor.authorCATROUX, M.
dc.contributor.authorGARCIA, M.
dc.contributor.authorGIRAUD, V.
dc.contributor.authorMARTELLOSIO, J.
dc.contributor.authorROBLOT, F.
dc.contributor.authorPASDELOUP, T.
dc.contributor.authorRICHÉ, A.
dc.contributor.authorGROSSET, M.
dc.contributor.authorMALES, S.
dc.contributor.authorNGO BELL, C.
dc.contributor.authorCARPENTIER, C.
dc.contributor.authorTUMIOTTO, C.
dc.contributor.authorMIREMEONT-SALAMÉ, G.
dc.contributor.authorARMA, D.
dc.contributor.authorARNOU, G.
dc.contributor.authorBLAIZEAU, M.J.
dc.contributor.authorCAMPS, P.
dc.contributor.authorDECOIN, M.
dc.contributor.authorDELVEAUX, S.
dc.contributor.authorDIARRA, F.
dc.contributor.authorGABREA, L.
dc.contributor.authorLAI, W.H.
dc.contributor.authorLENAUD, E.
dc.contributor.authorPLAINCHAMPS, D.
dc.contributor.authorPOUGETOUX, A.
dc.contributor.authorUWAMALIYA, B.
dc.contributor.authorZARA, K.
dc.contributor.authorCONTE, V.
dc.contributor.authorGAPILLOUT, M.
dc.date.accessioned2024-05-23T12:28:53Z
dc.date.available2024-05-23T12:28:53Z
dc.date.issued2023
dc.identifier.issn1471-2334en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/200016
dc.description.abstractEnBackground: To evaluate drug use (alcohol, tobacco, cannabis and other drugs) and its association with mean CD4/CD8 T cell count ratio, a marker of chronic inflammation, in virally suppressed people living with HIV-1 (PLWH) in Nouvelle Aquitaine, France. Methods: A multi-centric, cross-sectional analysis was conducted in 2018–19 in the QuAliV study—ANRS CO3 AQUIVIH-NA cohort. Tobacco, alcohol, cannabis, and other drug use (poppers, cocaine, amphetamines, synthetic cathinones, GHB/GBL) were self-reported. CD4 and CD8 T cell counts and viral load measures, ± 2 years of self-report, and other characteristics were abstracted from medical records. Univariable and multivariable linear regression models, adjusted for age, sex, HIV risk group, time since HIV diagnosis, and other drug use were fit for each drug and most recent CD4/CD8 ratio. Results: 660 PLWH, aged 54.7 ± 11.2, were included. 47.7% [315/660] had a CD4/CD8 ratio of < 1. Their mean CD4/CD8 ratio was 1.1 ± 0.6. 35% smoked; 40% were considered to be hazardous drinkers or have alcohol use disorder; 19.9% used cannabis and 11.9% other drugs. Chemsex-associated drug users’ CD4/CD8 ratio was on average 0.226 (95% confidence interval [95% CI] − 0.383, − 0.070) lower than that of non-users in univariable analysis (p = 0.005) and 0.165 lower [95% CI − 0.343, 0.012] in multivariable analysis (p = 0.068). Conclusions: Mean differences in CD4/CD8 ratio were not significantly different in tobacco, alcohol and cannabis users compared to non-users. However, Chemsex-associated drug users may represent a population at risk of chronic inflammation, the specific determinants of which merit further investigation. Trial registration number: NCT03296202. © 2023, The Author(s).
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enCD4/CD8 ratio
dc.subject.enChronic inflammation
dc.subject.enChemsex
dc.subject.enDrug use
dc.subject.enHIV
dc.title.enTobacco, alcohol, cannabis, and illicit drug use and their association with CD4/CD8 cell count ratio in people with controlled HIV: a cross-sectional study (ANRS CO3 AQUIVIH-NA-QuAliV)
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12879-022-07963-6en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed36624391en_US
bordeaux.journalBMC Infectious Diseasesen_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04590453
hal.version1
hal.date.transferred2024-05-28T10:01:45Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=BMC%20Infectious%20Diseases&amp;rft.date=2023&amp;rft.volume=23&amp;rft.issue=1&amp;rft.eissn=1471-2334&amp;rft.issn=1471-2334&amp;rft.au=DEVOS,%20Sophie&amp;BONNET,%20Fran%C3%A7ois&amp;HESSAMFAR,%20Mojgan&amp;NEAU,%20D.&amp;VAREIL,%20M.-O.&amp;rft.genre=article


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