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Thermosensitive polymer-grafted iron oxide nanoparticles studied by in situ dynamic light backscattering under magnetic hyperthermia

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorHEMERY, Gauvin
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorGARANGER, Elisabeth
IDREF: 089451740
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.contributor.authorWONG, Andrew
dc.contributor.authorGILLIES, Elizabeth
hal.structure.identifierCordouan Technologies
dc.contributor.authorPEDRONO, Boris
hal.structure.identifierCordouan Technologies
dc.contributor.authorBAYLE, Thomas
hal.structure.identifierCordouan Technologies
dc.contributor.authorJACOB, David
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2015
dc.identifier.issn0022-3727
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19996
dc.description.abstractEnThermometry at the nanoscale is an emerging area fostered by intensive research on nanoparticles (NPs) that are capable of converting electromagnetic waves into heat. Recent results suggest that stationary gradients can be maintained between the surface of NPs and the bulk solvent, a phenomenon sometimes referred to as ` cold hyperthermia'. However, the measurement of such highly localized temperatures is particularly challenging. We describe here a new approach to probing the temperature at the surface of iron oxide NPs and enhancing the understanding of this phenomenon. This approach involves the grafting of thermosensitive polymer chains to the NP surface followed by the measurement of macroscopic properties of the resulting NP suspension and comparison to a calibration curve built up by macroscopic heating. Superparamagnetic iron oxide NPs were prepared by the coprecipitation of ferrous and ferric salts and functionalized with amines, then azides using a sol-gel route followed by a dehydrative coupling reaction. Thermosensitive poly[2-(dimethylamino) ethyl methacrylate] (PDMAEMA) with an alkyne end-group was synthesized by controlled radical polymerization and was grafted using a copper assisted azide-alkyne cycloaddition reaction. Measurement of the colloidal properties by dynamic light scattering (DLS) indicated that the thermosensitive NPs exhibited changes in their Zeta potential and hydrodynamic diameter as a function of pH and temperature due to the grafted PDMAEMA chains. These changes were accompanied by changes in the relaxivities of the NPs, suggesting application as thermosensitive contrast agents for magnetic resonance imaging (MRI). In addition, a new fibre-based backscattering setup enabled positioning of the DLS remote-head as close as possible to the coil of a magnetic heating inductor to afford in situ probing of the backscattered light intensity, hydrodynamic diameter, and temperature. This approach provides a promising platform for estimating the response of magnetic NPs to application of a radiofrequency magnetic field or for understanding the behaviour of other thermogenic NPs.
dc.description.sponsorshipMagnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017
dc.language.isoen
dc.publisherIOP Publishing
dc.subject.ensol-gel and click chemistry
dc.subject.enCONTRAST AGENTS
dc.subject.enmagnetic nanoparticles
dc.subject.enMRI
dc.subject.enCATALYSIS
dc.subject.enthermosensitive polymers
dc.subject.enmagnetic hyperthermia
dc.subject.endynamic light scattering
dc.subject.enlight backscattering
dc.subject.enradiofrequency magnetic field
dc.title.enThermosensitive polymer-grafted iron oxide nanoparticles studied by in situ dynamic light backscattering under magnetic hyperthermia
dc.typeArticle de revue
dc.identifier.doi10.1088/0022-3727/48/49/494001
dc.subject.halChimie/Polymères
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Science des matériaux [cond-mat.mtrl-sci]
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalJournal of Physics D: Applied Physics
bordeaux.page494001
bordeaux.volume48
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue49
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01361281
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01361281v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Physics%20D:%20Applied%20Physics&rft.date=2015&rft.volume=48&rft.issue=49&rft.spage=494001&rft.epage=494001&rft.eissn=0022-3727&rft.issn=0022-3727&rft.au=HEMERY,%20Gauvin&GARANGER,%20Elisabeth&LECOMMANDOUX,%20Sebastien&WONG,%20Andrew&GILLIES,%20Elizabeth&rft.genre=article


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