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dc.rights.licenseopenen_US
dc.contributor.authorIRIART, Xavier
dc.contributor.authorBLANC, Gregoire
dc.contributor.authorBOUTEILLER, Xavier Paul
dc.contributor.authorLEGGHE, Benoit
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBOUYER, Benjamin
dc.contributor.authorSRIDI-CHENITI, Soumaya
dc.contributor.authorBUSTIN, Aurelien
dc.contributor.authorVASILE, Corina
dc.contributor.authorTHAMBO, Jean-Benoit
dc.contributor.authorELBAZ, Meyer
dc.contributor.authorCOCHET, Hubert
dc.date.accessioned2024-05-22T07:42:07Z
dc.date.available2024-05-22T07:42:07Z
dc.date.issued2023-09-01
dc.identifier.issn1527-1315en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199967
dc.description.abstractEnBackground: At follow-up CT after left atrial appendage occlusion (LAAO), hypoattenuation thickening (HAT) on the atrial aspect of the device is a common finding but the clinical implications require further study. Purpose: To assess the association of HAT grade at follow-up CT with clinical characteristics and outcomes in patients who underwent LAAO. Materials and Methods: This prospective study included consecutive participants with atrial fibrillation and who were at high risk for stroke (CHA 2DS 2-VASc score >= 4) who underwent LAAO and were administered pacifier or nonpacifier devices at two French medical centers between January 2012 and November 2020. Postprocedure CT images were evaluated by two radiologists in consensus and device-specific interpretation algorithms were applied to classify HAT as low grade (low suspicion of thrombosis) or high grade (high suspicion of thrombosis). The association between HAT grade and clinical characteristics was assessed using multinomial logistic regression, and variables associated with risk of stroke were assessed using a Cox proportional hazard model. Results: This study included 412 participants (mean age, 76 years +/- 8 [SD]; 284 male participants) who underwent follow-up CT at a mean of 4.2 months +/- 1.7 after LAAO. Low-grade and high-grade HAT were depicted in 98 of 412 (23.8%) and 21 of 412 (5.1%) participants, respectively. High-grade HAT was associated with higher odds of antithrombotic drug discontinuation during follow-up (odds ratio, 9.5; 95% CI: 3.1, 29.1; P <.001), whereas low-grade HAT was associated with lower odds of persisting left atrial appendage patency (odds ratio, 0.46; 95% CI: 0.27, 0.79; P = .005). During a median follow-up of 17 months (IQR, 11-41 months), stroke occurred in 24 of 412 (5.8%) participants. High-grade HAT was associated with stroke (hazard ratio, 4.6; 95% CI: 1.5, 14.0; P = .008) and low-grade HAT (P = .62) was not. Conclusion: Low-grade HAT was a more common finding at CT performed after LAAO CT (24%) than was high-grade HAT (5%), but it was associated with more favorable outcomes than high-grade HAT, which was associated with higher stroke risk. (c) RSNA, 2023
dc.language.isoENen_US
dc.title.enClinical Implications of CT-detected Hypoattenuation Thickening on Left Atrial Appendage Occlusion Devices
dc.title.alternativeRadiologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1148/radiol.230462en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37668517en_US
bordeaux.journalRadiologyen_US
bordeaux.pagee230462en_US
bordeaux.volume308en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04582703
hal.version1
hal.date.transferred2024-05-22T07:42:10Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Radiology&amp;rft.date=2023-09-01&amp;rft.volume=308&amp;rft.issue=3&amp;rft.spage=e230462&amp;rft.epage=e230462&amp;rft.eissn=1527-1315&amp;rft.issn=1527-1315&amp;rft.au=IRIART,%20Xavier&amp;BLANC,%20Gregoire&amp;BOUTEILLER,%20Xavier%20Paul&amp;LEGGHE,%20Benoit&amp;BOUYER,%20Benjamin&amp;rft.genre=article


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