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Synthesis and self-assembly of Xylan-based amphiphiles: from bio-based vesicles to antifungal properties

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hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorROSSELGONG, Julien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorCHEMIN, Maud
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorCABRAL ALMADA, Cédric
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorHEMERY, Gauvin
hal.structure.identifierInstitut de minéralogie, de physique des matériaux et de cosmochimie [IMPMC]
dc.contributor.authorGUIGNER, Jean-Michel
hal.structure.identifierInstitut des corps gras [ITERG]
dc.contributor.authorCHOLLET, Guillaume
hal.structure.identifierInstitut Technologique Forêt Cellulose Bois-construction Ameublement [FCBA]
dc.contributor.authorLABAT, Gilles
hal.structure.identifierInstitut Technologique Forêt Cellulose Bois-construction Ameublement [FCBA]
dc.contributor.authorDA SILVA PEREZ, Denilson
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorHAM-PICHAVANT, Frédérique
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorGRAU, Etienne
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorGRELIER, Stéphane
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 2 LCPO : Biopolymers & Bio-sourced Polymers
dc.contributor.authorCRAMAIL, Henri
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2019
dc.identifier.issn1525-7797
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19993
dc.description.abstractEnThis work aims at designing functional biomaterials through selective chemical modification of xylan from beechwood. Acidic hydrolysis of xylan leaded to well-defined oligomers with an average of six xylose units per chain and with an aldehyde group at the reductive end. Reductive amination was performed on this aldehyde end-group to introduce an azide reactive group. 'Click chemistry' was then applied to couple these hydrophilic xylans moieties with different hydrophobic fatty acid methyl esters that were previously functionalized with complementary alkyne functions. The resulting amphiphilic bio-based conjugates were then self-assembled using three different methods, namely direct solubilization, thin-film rehydration/extrusion and microfluidics. Well -defined micelles and vesicles were obtained and their high loading capacity with propiconazole as an antifungal active molecule was shown. The resulting vesicles loaded with propiconazole in a microfluidic process, proved to significantly improve the antifungal activity of propiconazole, demonstrating the high potential of such xylan-based amphiphiles.
dc.description.sponsorshipPlateforme d’Innovation « Forêt-Bois-Fibre-Biomasse du Futur »
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.title.enSynthesis and self-assembly of Xylan-based amphiphiles: from bio-based vesicles to antifungal properties
dc.typeArticle de revue
dc.identifier.doi10.1021/acs.biomac.8b01210
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halPhysique [physics]/Matière Condensée [cond-mat]/Matière Molle [cond-mat.soft]
bordeaux.journalBiomacromolecules
bordeaux.page118-129
bordeaux.volume20
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue1
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01906661
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01906661v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Biomacromolecules&rft.date=2019&rft.volume=20&rft.issue=1&rft.spage=118-129&rft.epage=118-129&rft.eissn=1525-7797&rft.issn=1525-7797&rft.au=ROSSELGONG,%20Julien&CHEMIN,%20Maud&CABRAL%20ALMADA,%20C%C3%A9dric&HEMERY,%20Gauvin&GUIGNER,%20Jean-Michel&rft.genre=article


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