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Proteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital

hal.structure.identifierCentre for Marine and Environmental Research [Faro] [CIMA]
dc.contributor.authorBEBIANNO, Maria João
hal.structure.identifierLaboratoire d'Ecologie Alpine [LECA ]
dc.contributor.authorSRODA, Sophie
hal.structure.identifierCentre for Marine and Environmental Research [Faro] [CIMA]
dc.contributor.authorGOMES, T.
hal.structure.identifierPlate-forme de Protéomique PISSARO
dc.contributor.authorCHAN, P.
hal.structure.identifierBiochimie et Toxicologie des Substances Bioactives [BTSB]
dc.contributor.authorBONNAFÉ, Elsa
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
hal.structure.identifierGéographie de l'environnement [GEODE]
hal.structure.identifierInstitut national universitaire Champollion [Albi] [INUC]
dc.contributor.authorGERET, Florence
dc.date.accessioned2024-05-15T12:19:50Z
dc.date.available2024-05-15T12:19:50Z
dc.date.issued2016-03
dc.identifier.issn0944-1344
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199878
dc.description.abstractEnThe increase use of pharmaceutical compounds in veterinary practice and human population results in the ubiquitous presence of these compounds in aquatic ecosystems. Because pharmaceuticals are highly bioactive, there is concern about their toxicological effects in aquatic organisms. Therefore, the aim of this study was to assess the effects of an effluent from a psychiatric hospital (containing a complex mixture of 25 pharmaceutical compounds from eleven therapeutic classes) on the freshwater clam Corbicula fluminea using a proteomic approach. The exposure of C. fluminea to this complex effluent containing anxiolytics, analgesics, lipid regulators, beta blockers, antidepressants, antiepileptics, antihistamines, antihypertensives, antiplatelets and antiarrhythmics induced protein changes after 1 day of exposure in clam gills and digestive gland more evident in the digestive gland. These changes included increase in the abundance of proteins associated with structural (actin and tubulin), cellular functions (calreticulin, proliferating cell nuclear antigen (PCNA), T complex protein 1 (TCP1)) and metabolism (aldehyde dehydrogenase (ALDH), alcohol dehydrogenase, 6 phosphogluconate dehydrogenase). Results from this study indicate that calreticulin, PCNA, ALDH and alcohol dehydrogenase in the digestive gland and T complex protein 1 (TCP1)) and 6 phosphogluconate dehydrogenase in the gills represent useful biomarkers for the ecotoxicological characterization of psychiatric hospital effluents in this species.
dc.language.isoen
dc.publisherSpringer Verlag
dc.subject.enCorbicula fluminea
dc.subject.enProteomics
dc.subject.enHospital effluent
dc.subject.enPharmaceutical compounds
dc.title.enProteomic changes in Corbicula fluminea exposed to wastewater from a psychiatric hospital
dc.typeArticle de revueen_US
dc.identifier.doi10.1007/s11356-015-5395-5
dc.subject.halSciences du Vivant [q-bio]/Toxicologie/Ecotoxicologie
dc.subject.halSciences du Vivant [q-bio]/Sciences pharmaceutiques/Médicaments
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Zoologie des invertébrés
bordeaux.journalEnvironmental Science and Pollution Researchen_US
bordeaux.page5046-5055
bordeaux.volume23
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue6
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-02419029
hal.version1
hal.popularnon
hal.audienceInternationale
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Environmental%20Science%20and%20Pollution%20Research&rft.date=2016-03&rft.volume=23&rft.issue=6&rft.spage=5046-5055&rft.epage=5046-5055&rft.eissn=0944-1344&rft.issn=0944-1344&rft.au=BEBIANNO,%20Maria%20Jo%C3%A3o&SRODA,%20Sophie&GOMES,%20T.&CHAN,%20P.&BONNAF%C3%89,%20Elsa&rft.genre=article


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