Afficher la notice abrégée

Cushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome

dc.rights.licenseopenen_US
dc.contributor.authorAMODRU, Vincent
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorFERRIERE, Amandine
dc.contributor.authorTABARIN, Antoine
dc.contributor.authorCASTINETTI, Frederic
dc.contributor.authorTSAGARAKIS, Stylianos
dc.contributor.authorTOTH, Miklos
dc.contributor.authorFEELDERS, Richard A.
dc.contributor.authorWEBB, Susan M.
dc.contributor.authorREINCKE, Martin
dc.contributor.authorNETEA-MAIER, Romana
dc.contributor.authorKASTELAN, Darko
dc.contributor.authorELENKOVA, Atanaska
dc.contributor.authorMAITER, Dominique
dc.contributor.authorRAGNARSSON, Oskar
dc.contributor.authorSANTOS, Alicia
dc.contributor.authorVALASS, Elena
dc.contributor.authorGRP, Ercusyn Study
dc.date.accessioned2024-05-15T09:40:14Z
dc.date.available2024-05-15T09:40:14Z
dc.date.issued2023-02
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199870
dc.description.abstractEnObjective To evaluate whether age-related differences exist in clinical characteristics, diagnostic approach, and management strategies in patients with Cushing's syndrome (CS) included in the European Registry on Cushing's Syndrome (ERCUSYN). Design Cohort study. Methods We analyzed 1791 patients with CS, of whom 1234 (69%) had pituitary-dependent CS (PIT-CS), 450 (25%) adrenal-dependent CS (ADR-CS), and 107 (6%) had an ectopic source (ECT-CS). According to the WHO criteria, 1616 patients (90.2%) were classified as younger (<65 years old) and 175 (9.8%) as older (≥65 years old). Results Older patients were more frequently males and had a lower Body Mass Index (BMI) and waist circumference when compared with the younger. Older patients also had a lower prevalence of skin alterations, depression, hair loss, hirsutism, and reduced libido, but a higher prevalence of muscle weakness, diabetes, hypertension, cardiovascular disease, venous thromboembolism, and bone fractures than younger patients, regardless of sex (P < .01 for all comparisons). Measurement of urinary free cortisol supported the diagnosis of CS less frequently in older patients when compared with the younger (P < .05). An extrasellar macroadenoma (macrocorticotropinoma with extrasellar extension) was more common in older PIT-CS patients than in the younger (P < .01). Older PIT-CS patients more frequently received cortisol-lowering medications and radiotherapy as a first-line treatment, whereas surgery was the preferred approach in the younger (P < .01 for all comparisons). When transsphenoidal surgery was performed, the remission rate was lower in the elderly when compared with their younger counterpart (P < .05). Conclusions Older CS patients lack several typical symptoms of hypercortisolism, present with more comorbidities regardless of sex, and are more often conservatively treated.
dc.language.isoENen_US
dc.subject.enCushing’s disease
dc.subject.enaging
dc.subject.enErcusyn
dc.subject.enelderly patients
dc.title.enCushing's syndrome in the elderly: data from the European Registry on Cushing's syndrome
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/ejendo/lvad008en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
bordeaux.journalEuropean Journal of Endocrinologyen_US
bordeaux.page395-406en_US
bordeaux.volume188en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue4en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=European%20Journal%20of%20Endocrinology&amp;rft.date=2023-02&amp;rft.volume=188&amp;rft.issue=4&amp;rft.spage=395-406&amp;rft.epage=395-406&amp;rft.au=AMODRU,%20Vincent&amp;FERRIERE,%20Amandine&amp;TABARIN,%20Antoine&amp;CASTINETTI,%20Frederic&amp;TSAGARAKIS,%20Stylianos&amp;rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
ImmunoConcept_EURJEndocrinol_2 ...
Taille:
4.437Mo
Format:
PDF
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée