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Nano-thermometers with thermo-sensitive polymer grafted USPIOs behaving as positive contrast agents in low-field MRI

dc.rights.licenseopen
dc.contributor.authorHANNECART, Adeline
dc.contributor.authorSTANICKI, Dimitri
dc.contributor.authorVANDER ELST, Luce
dc.contributor.authorMULLER, Robert N.
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorTHEVENOT, Julie
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBONDUELLE, Colin
IDREF: 134527046
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorTROTIER, Aurelien
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMASSOT, Philippe
hal.structure.identifierCentre de résonance magnétique des systèmes biologiques [CRMSB]
dc.contributor.authorMIRAUX, Sylvain
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorSANDRE, Olivier
dc.contributor.authorLAURENT, Sophie
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2015
dc.identifier.issn2040-3364
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19982
dc.description.abstractEnTwo commercial statistical copolymers of ethylene oxide and propylene oxide, Jeffamine (R) M-2005 (PEO5-st-PPO37) and M-2070 (PEO46-st-PPO13), exhibiting lower critical solution temperature (LCST) in water, were grafted onto the surface of ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) using silanization and amide-bond coupling reactions. The LCSTs of the polymers in solution were measured by dynamic light scattering (DLS) and nuclear magnetic resonance (NMR). In accordance with the compositions of EO vs. PO, the transition temperature was measured to be 22 +/- 2 degrees C for M-2005 by both DLS and NMR, while the LCST was much higher, 52 +/- 2 degrees C, for M-2070 (a second transition was also detected above 80 degrees C by NMR in that case, ascribed to the full dehydration of chains at the molecular level). The resulting polymer-grafted USPIOs exhibit a temperature-responsive colloidal behaviour, their surface reversibly changing from hydrophilic below LCST to hydrophobic above it. This phenomenon was utilised to design thermo-sensitive contrast agents for MRI. Transverse relaxivities (r(2)) of the USPIO@PEO5-st-PPO37 core-shell nanoparticles were measured at 8.25, 20, 60, and 300 MHz. Nuclear magnetic resonance dispersion (NMRD) profiles, giving longitudinal relaxivities (r(1)) between 0.01 and 60 MHz, were acquired at temperatures ranging from 15 to 50 degrees C. For all tested frequencies except 300 MHz, both r(1) and r(2) decrease with temperature and show an inflection point at 25 degrees C, near the LCST. To illustrate the interest of such polymer-coated USPIOs for MRI thermometry, sample tubes were imaged on both low-field (8.25 MHz/0.194 Tesla) and high-field (300 MHz/7.05 Tesla) MRI scanners with either T-1-or T-2*-weighted spin echo sequences. The positive contrast on low-field MR images and the perfect linearity of the signal with a T-2*-weighted sequence over the entire temperature range 15-50 degrees C render these LCST polymer coated USPIOs interesting positive contrast agents, also working as "nano-thermometers".
dc.description.sponsorshipMagnéto-Chimiothérapie : Modélisation de la Délivrance Induite par Champ Magnétique Radiofréquence d'Anticancéreux par des Nano-Vésicules Polymères et Suivi par IRM d'un Modèle de Glioblastome - ANR-13-BS08-0017
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.subject.enTHERMOMETRY
dc.subject.enMRI CONTRAST AGENTS
dc.subject.enBLOCK-COPOLYMERS
dc.subject.enBIOMEDICAL APPLICATIONS
dc.subject.enDRUG-DELIVERY
dc.subject.enSUPERPARAMAGNETIC PARTICLES
dc.subject.enMAGNETIC NANOPARTICLES
dc.subject.enIRON-OXIDE NANOPARTICLES
dc.subject.enWATER DIFFUSIVITY
dc.subject.enPROTON RELAXATION
dc.subject.enSURFACE FUNCTIONALIZATION
dc.title.enNano-thermometers with thermo-sensitive polymer grafted USPIOs behaving as positive contrast agents in low-field MRI
dc.typeArticle de revue
dc.identifier.doi10.1039/c4nr07064j
dc.subject.halChimie/Polymères
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Chimie théorique et/ou physique
dc.subject.halSciences du Vivant [q-bio]/Ingénierie biomédicale/Imagerie
dc.description.sponsorshipEuropeMultifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy
bordeaux.journalNanoscale
bordeaux.page3754-3767
bordeaux.volume7
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue8
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01361815
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01361815v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanoscale&rft.date=2015&rft.volume=7&rft.issue=8&rft.spage=3754-3767&rft.epage=3754-3767&rft.eissn=2040-3364&rft.issn=2040-3364&rft.au=HANNECART,%20Adeline&STANICKI,%20Dimitri&VANDER%20ELST,%20Luce&MULLER,%20Robert%20N.&LECOMMANDOUX,%20Sebastien&rft.genre=article


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