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Impact of Preformed Donor-Specific Anti-HLA-Cw and Anti-HLA-DP Antibodies on Acute Antibody-Mediated Rejection in Kidney Transplantation
dc.rights.license | open | en_US |
dc.contributor.author | LABOUX, Timothee | |
dc.contributor.author | LENAIN, Remi | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | VISENTIN, Jonathan | |
dc.contributor.author | FLAHAUT, Gauthier | |
dc.contributor.author | CHAMLEY, Paul | |
dc.contributor.author | PROVÔT, François | |
dc.contributor.author | TOP, Isabelle | |
dc.contributor.author | KERLEAU, Clarisse | |
dc.contributor.author | LABALETTE, Myriam | |
dc.contributor.author | CHOUKROUN, Gabriel | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | COUZI, Lionel | |
dc.contributor.author | BLANCHO, Gilles | |
dc.contributor.author | HAZZAN, Marc | |
dc.contributor.author | MAANAOUI, Mehdi | |
dc.date.accessioned | 2024-05-14T13:01:20Z | |
dc.date.available | 2024-05-14T13:01:20Z | |
dc.date.issued | 2023-11 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199823 | |
dc.description.abstractEn | Given the risk of rejection, the presence of preformed donor specific antibodies (DSA) contraindicates transplantation in most allocation systems. However, HLA-Cw and -DP DSA escape this censorship. We performed a multicentric observational study, in which the objective was to determinate risk factors of acute antibody-mediated rejection (aABMR) in recipients transplanted with preformed isolated Cw- or DP-DSA. Between 2010 and 2019, 183 patients were transplanted with a preformed isolated Cw- or DP-DSA (92 Cw-DSA; 91 DP-DSA). At 2 years, the incidence of aABMR was 12% in the Cw-DSA group, versus 28% in the DP-DSA group. Using multivariable Cox regression model, the presence of a preformed DP-DSA was associated with an increased risk of aABMR (HR = 2.32 [1.21–4.45 (p = 0.001)]) compared with Cw-DSA. We also observed a significant association between the DSA’s MFI on the day of transplant and the risk of aABMR (HR = 1.09 [1.08–1.18], p = 0.032), whatever the DSA was. Interaction term analysis found an increased risk of aABMR in the DP-DSA group compared with Cw-DSA, but only for MFI below 3,000. These results may plead for taking these antibodies into account in the allocation algorithms, in the same way as other DSA. Copyright © 2023 Laboux, Lenain, Visentin, Flahaut, Chamley, Provôt, Top, Kerleau, Labalette, Choukroun, Couzi, Blancho, Hazzan and Maanaoui. | |
dc.language.iso | EN | en_US |
dc.rights | Attribution 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
dc.subject.en | Donor-specific antibodies | |
dc.subject.en | kidney transplant | |
dc.subject.en | acute antibody-mediated rejection | |
dc.subject.en | HLA-Cw | |
dc.subject.en | HLA-DP | |
dc.title.en | Impact of Preformed Donor-Specific Anti-HLA-Cw and Anti-HLA-DP Antibodies on Acute Antibody-Mediated Rejection in Kidney Transplantation | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.3389/ti.2023.11416 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
bordeaux.journal | Transplant International | en_US |
bordeaux.page | 11416 | en_US |
bordeaux.volume | 36 | en_US |
bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.popular | non | en_US |
hal.audience | Internationale | en_US |
hal.export | false | |
dc.rights.cc | CC BY | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Transplant%20International&rft.date=2023-11&rft.volume=36&rft.spage=11416&rft.epage=11416&rft.au=LABOUX,%20Timothee&LENAIN,%20Remi&VISENTIN,%20Jonathan&FLAHAUT,%20Gauthier&CHAMLEY,%20Paul&rft.genre=article |