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Long-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study

dc.rights.licenseopenen_US
dc.contributor.authorTAN, Byorn W L
dc.contributor.authorTAN, Bryce W Q
dc.contributor.authorTAN, Amelia L M
dc.contributor.authorSCHRIVER, Emily R
dc.contributor.authorGUTIERREZ-SACRISTAN, Alba
dc.contributor.authorDAS, Priyam
dc.contributor.authorYUAN, William
dc.contributor.authorHUTCH, Meghan R
dc.contributor.authorGARCIA BARRIO, Noelia
dc.contributor.authorPEDRERA JIMENEZ, Miguel
dc.contributor.authorABU-EL-RUB, Noor
dc.contributor.authorMORRIS, Michele
dc.contributor.authorMOAL, Bertrand
dc.contributor.authorVERDY, Guillaume
dc.contributor.authorCHO, Kelly
dc.contributor.authorHO, Yuk-Lam
dc.contributor.authorPATEL, Lav P
dc.contributor.authorDAGLIATI, Arianna
dc.contributor.authorNEURAZ, Antoine
dc.contributor.authorKLANN, Jeffrey G
dc.contributor.authorSOUTH, Andrew M
dc.contributor.authorVISWESWARAN, Shyam
dc.contributor.authorHANAUER, David A
dc.contributor.authorMAIDLOW, Sarah E
dc.contributor.authorLIU, Mei
dc.contributor.authorMOWERY, Danielle L
dc.contributor.authorBATUGO, Ashley
dc.contributor.authorMAKOUDJOU, Adeline
dc.contributor.authorTIPPMANN, Patric
dc.contributor.authorZOLLER, Daniela
dc.contributor.authorBRAT, Gabriel A
dc.contributor.authorLUO, Yuan
dc.contributor.authorAVILLACH, Paul
dc.contributor.authorBELLAZZI, Riccardo
dc.contributor.authorCHIOVATO, Luca
dc.contributor.authorMALOVINI, Alberto
dc.contributor.authorTIBOLLO, Valentina
dc.contributor.authorSAMAYAMUTHU, Malarkodi Jebathilagam
dc.contributor.authorSERRANO BALAZOTE, Pablo
dc.contributor.authorXIA, Zongqi
dc.contributor.authorLOH, Ne Hooi Will
dc.contributor.authorCHIUDINELLI, Lorenzo
dc.contributor.authorBONZEL, Clara-Lea
dc.contributor.authorHONG, Chuan
dc.contributor.authorZHANG, Harrison G
dc.contributor.authorWEBER, Griffin M
dc.contributor.authorKOHANE, Isaac S
dc.contributor.authorCAI, Tianxi
dc.contributor.authorOMENN, Gilbert S
dc.contributor.authorHOLMES, John H
dc.contributor.authorNGIAM, Kee Yuan
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRIFFIER, Romain
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorJOUHET, Vianney
dc.date.accessioned2024-05-14T07:19:57Z
dc.date.available2024-05-14T07:19:57Z
dc.date.issued2023-01-01
dc.identifier.issn2589-5370en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199810
dc.description.abstractEnBACKGROUND: While acute kidney injury (AKI) is a common complication in COVID-19, data on post-AKI kidney function recovery and the clinical factors associated with poor kidney function recovery is lacking. METHODS: A retrospective multi-centre observational cohort study comprising 12,891 hospitalized patients aged 18 years or older with a diagnosis of SARS-CoV-2 infection confirmed by polymerase chain reaction from 1 January 2020 to 10 September 2020, and with at least one serum creatinine value 1-365 days prior to admission. Mortality and serum creatinine values were obtained up to 10 September 2021. FINDINGS: Advanced age (HR 2.77, 95%CI 2.53-3.04, p < 0.0001), severe COVID-19 (HR 2.91, 95%CI 2.03-4.17, p < 0.0001), severe AKI (KDIGO stage 3: HR 4.22, 95%CI 3.55-5.00, p < 0.0001), and ischemic heart disease (HR 1.26, 95%CI 1.14-1.39, p < 0.0001) were associated with worse mortality outcomes. AKI severity (KDIGO stage 3: HR 0.41, 95%CI 0.37-0.46, p < 0.0001) was associated with worse kidney function recovery, whereas remdesivir use (HR 1.34, 95%CI 1.17-1.54, p < 0.0001) was associated with better kidney function recovery. In a subset of patients without chronic kidney disease, advanced age (HR 1.38, 95%CI 1.20-1.58, p < 0.0001), male sex (HR 1.67, 95%CI 1.45-1.93, p < 0.0001), severe AKI (KDIGO stage 3: HR 11.68, 95%CI 9.80-13.91, p < 0.0001), and hypertension (HR 1.22, 95%CI 1.10-1.36, p = 0.0002) were associated with post-AKI kidney function impairment. Furthermore, patients with COVID-19-associated AKI had significant and persistent elevations of baseline serum creatinine 125% or more at 180 days (RR 1.49, 95%CI 1.32-1.67) and 365 days (RR 1.54, 95%CI 1.21-1.96) compared to COVID-19 patients with no AKI. INTERPRETATION: COVID-19-associated AKI was associated with higher mortality, and severe COVID-19-associated AKI was associated with worse long-term post-AKI kidney function recovery. FUNDING: Authors are supported by various funders, with full details stated in the acknowledgement section.
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
dc.subject.enAcute kidney injury
dc.subject.enCOVID-19
dc.subject.enChronic kidney disease
dc.subject.enElectronic health records
dc.subject.enSARS-CoV-2
dc.title.enLong-term kidney function recovery and mortality after COVID-19-associated acute kidney injury: An international multi-centre observational cohort study
dc.title.alternativeEClinicalMedicineen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.eclinm.2022.101724en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed36381999en_US
bordeaux.journalEClinicalMedicineen_US
bordeaux.page101724en_US
bordeaux.volume55en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamAHEAD_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDNational Institutes of Healthen_US
hal.identifierhal-04574714
hal.version1
hal.date.transferred2024-05-14T12:00:07Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=EClinicalMedicine&amp;rft.date=2023-01-01&amp;rft.volume=55&amp;rft.spage=101724&amp;rft.epage=101724&amp;rft.eissn=2589-5370&amp;rft.issn=2589-5370&amp;rft.au=TAN,%20Byorn%20W%20L&amp;TAN,%20Bryce%20W%20Q&amp;TAN,%20Amelia%20L%20M&amp;SCHRIVER,%20Emily%20R&amp;GUTIERREZ-SACRISTAN,%20Alba&amp;rft.genre=article


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