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Polymersome Popping by Light-Induced Osmotic Shock under Temporal, Spatial, and Spectral Control

dc.rights.licenseopen
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorPEYRET, Ariane
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorIBARBOURE, Emmanuel
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorTRON, Arnaud
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorBEAUTÉ, Louis
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorRUST, Ruben
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
dc.contributor.authorSANDRE, Olivier
hal.structure.identifierInstitut des Sciences Moléculaires [ISM]
dc.contributor.authorMCCLENAGHAN, Nathan
hal.structure.identifierLaboratoire de Chimie des Polymères Organiques [LCPO]
hal.structure.identifierTeam 3 LCPO : Polymer Self-Assembly & Life Sciences
dc.contributor.authorLECOMMANDOUX, Sebastien
dc.date.accessioned2020
dc.date.available2020
dc.date.issued2017
dc.identifier.issn1433-7851
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/19975
dc.description.abstractEnThe light-triggered, programmable rupture of cellsized vesicles is described, with particular emphasis on selfassembled polymersome capsules. The mechanism involves a hypotonic osmotic imbalance created by the accumulation of photogenerated species inside the lumen, which cannot be compensated owing to the low water permeability of the membrane. This simple and versatile mechanism can be adapted to a wealth of hydrosoluble molecules, which are either able to generate reactive oxygen species or undergo photocleavage. Ultimately, in a multi-compartmentalized and cell-like system, the possibility to selectively burst polymersomes with high specificity and temporal precision and to consequently deliver small encapsulated vesicles (both polymersomes and liposomes) is demonstrated.
dc.description.sponsorshipDéveloppement de cellule synthétique comme micro-réacteur pour l'étude de l'activité enzymatique des NO-synthases et la compréhension de leur fonctionnement en conditions physiologiques - ANR-14-CE16-0015
dc.language.isoen
dc.publisherWiley-VCH Verlag
dc.subject.enMembrane proes
dc.subject.enPolymerosomes
dc.subject.enLiposomes
dc.subject.enOsmotic pressure
dc.subject.enPhotochemistry
dc.subject.enCoumarin
dc.subject.enUncaging
dc.title.enPolymersome Popping by Light-Induced Osmotic Shock under Temporal, Spatial, and Spectral Control
dc.typeArticle de revue
dc.identifier.doi10.1002/ange.201609231
dc.subject.halChimie/Matériaux
dc.subject.halChimie/Polymères
bordeaux.journalAngewandte Chemie International Edition
bordeaux.page1566-1570
bordeaux.volume56
bordeaux.hal.laboratoriesLaboratoire de Chimie des Polymères Organiques (LCPO) - UMR 5629*
bordeaux.issue6
bordeaux.institutionBordeaux INP
bordeaux.institutionUniversité de Bordeaux
bordeaux.peerReviewedoui
hal.identifierhal-01418924
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-01418924v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Angewandte%20Chemie%20International%20Edition&rft.date=2017&rft.volume=56&rft.issue=6&rft.spage=1566-1570&rft.epage=1566-1570&rft.eissn=1433-7851&rft.issn=1433-7851&rft.au=PEYRET,%20Ariane&IBARBOURE,%20Emmanuel&TRON,%20Arnaud&BEAUT%C3%89,%20Louis&RUST,%20Ruben&rft.genre=article


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