CRP under 130 mg/L rules out the diagnosis of Legionella pneumophila serogroup 1 (URINELLA Study)
| dc.rights.license | open | en_US |
| dc.contributor.author | KLOPFENSTEIN, Timothee | |
| dc.contributor.author | ZAYET, Souheil | |
| dc.contributor.author | POLONI, Samantha | |
| dc.contributor.author | GENDRIN, Vincent | |
| dc.contributor.author | FOURNIER, Damien | |
| dc.contributor.author | VUILLEMENOT, Jean-Baptiste | |
| dc.contributor.author | SELLES, Philippe | |
| dc.contributor.author | DUSSAUCY, Alain | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | COUREAU, Gaelle | |
| hal.structure.identifier | Statistics In System biology and Translational Medicine [SISTM] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AVALOS FERNANDEZ, Marta | |
| dc.contributor.author | TOKO, Lynda | |
| dc.contributor.author | ROYER, Pierre-Yves | |
| dc.contributor.author | LAVOIGNET, Charles-Eric | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AMARI, Bouchra | |
| dc.contributor.author | PUYRAVEAU, Marc | |
| dc.contributor.author | CHIROUZE, Catherine | |
| dc.date.accessioned | 2024-05-06T11:26:57Z | |
| dc.date.available | 2024-05-06T11:26:57Z | |
| dc.date.issued | 2024-03-26 | |
| dc.identifier.issn | 1435-4373 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199656 | |
| dc.description.abstractEn | INTRODUCTION: In case of pneumonia, some biological findings are suggestive for Legionnaire's disease (LD) including C-reactive protein (CRP). A low level of CRP is predictive for negative Legionella Urinary-Antigen-Test (L-UAT). METHOD: Observational retrospective study in Nord-Franche-Comté Hospital with external validation in Besançon University Hospital, France which included all adults with L-UAT performed during January 2018 to December 2022. The objective was to determine CRP optimal threshold to predict a L-UAT negative result. RESULTS: URINELLA included 5051 patients (83 with positive L-UAT). CRP optimal threshold was 131.9 mg/L, with a negative predictive value (NPV) at 100%, sensitivity at 100% and specificity at 58.0%. The AUC of the ROC-Curve was at 88.7% (95% CI, 86.3-91.1). External validation in Besançon Hospital patients showed an AUC at 89.8% (95% CI, 85.5-94.1) and NPV, sensitivity and specificity was respectively 99.9%, 97.6% and 59.1% for a CRP threshold at 131.9 mg/L; after exclusion of immunosuppressed patients, index sensitivity and NPV reached also 100%. CONCLUSION: In case of pneumonia suspicion with a CRP level under 130 mg/L (independently of the severity) L-UAT is useless in immunocompetent patients with a NPV at 100%. We must remain cautious in patients with symptoms onset less than 48 h before CRP dosage. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | C-reactive protein | |
| dc.subject.en | Legionellosis | |
| dc.subject.en | Legionnaire’s disease | |
| dc.subject.en | Negative Predictive Value | |
| dc.subject.en | Urinary Antigen Test | |
| dc.title.en | CRP under 130 mg/L rules out the diagnosis of Legionella pneumophila serogroup 1 (URINELLA Study) | |
| dc.title.alternative | Eur J Clin Microbiol Infect Dis | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1007/s10096-024-04814-x | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 38530466 | en_US |
| bordeaux.journal | European Journal of Clinical Microbiology & Infectious Diseases | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | INRIA | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.team | SISTM_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Clinical%20Microbiology%20&%20Infectious%20Diseases&rft.date=2024-03-26&rft.eissn=1435-4373&rft.issn=1435-4373&rft.au=KLOPFENSTEIN,%20Timothee&ZAYET,%20Souheil&POLONI,%20Samantha&GENDRIN,%20Vincent&FOURNIER,%20Damien&rft.genre=article |
