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Aqueous chlorination of sulfamethazine and sulfamethoxypyridazine: Kinetics and transformation products identification

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorNASSAR, Rania
dc.contributor.authorRIFAI, Ahmad
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorTRIVELLA, Aurelien
IDREF: 12328371X
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorMAZELLIER, Patrick
dc.contributor.authorMOKH, Samia
dc.contributor.authorAL-ISKANDARANI, Mohamad
dc.date.accessioned2024-05-06T09:59:17Z
dc.date.available2024-05-06T09:59:17Z
dc.date.issued2018-06-01
dc.identifier.issn1076-5174en_US
dc.identifier.urioai:crossref.org:10.1002/jms.4191
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199648
dc.description.abstractEnSulfonamides (SNs) are synthetic antimicrobial agents. These substances are continually introduced into the environment, and they may spread and maintain bacterial resistance in the different compartments. The chlorination of 2 SNs, namely, sulfamethazine (SMT) and sulfamethoxypyridazine (SMP), was investigated to study their reactivity with chlorine at typical concentrations for water treatment conditions. Experiments conducted in purified water show an acceleration of SMT and SMP degradation of a factor 1.5 by comparison to drinking water matrix. This difference is due to pH variation and competitive reactions between SNs and mineral and organic compounds, with chlorine in drinking water. In the presence of an excess of chlorine (6.7 μmol·L−1) in ultrapure water at pH 7.2, second-order degradation rate constants were equal to 4.5 × 102M−1·s−1 and 5.2 × 102M−1·s−1 for SMT and SMP, respectively. The structures of transformation products were investigated by liquid chromatography tandem mass spectrometry analyses with equimolar concentrations between chlorine and SNs. SO2 elimination, cyclization, and electrophilic substitutions were the main pathways of by-products formation. Moreover, the toxicity of the proposed structures was predicted by using toxicity estimation software tool program. The results indicated that most by-products may present developmental toxicity.
dc.language.isoENen_US
dc.sourcecrossref
dc.title.enAqueous chlorination of sulfamethazine and sulfamethoxypyridazine: Kinetics and transformation products identification
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/jms.4191en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalJournal of Mass Spectrometryen_US
bordeaux.page614-623en_US
bordeaux.volume53en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamLPTCen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04569369
hal.version1
hal.date.transferred2024-05-06T09:59:19Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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