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Prospective associations between ADHD symptoms and physical conditions from early childhood to adolescence: a population-based longitudinal study

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALERA, Cedric
ORCID: 0000-0003-0549-9608
IDREF: 110034007
dc.contributor.authorCOLLET, Ophelie
dc.contributor.authorORRI, Massimiliano
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorNAVARRO, Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCASTEL, Laura
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALESNE, Charline
dc.contributor.authorREED, Claire
dc.contributor.authorBRANDT, Valerie
dc.contributor.authorLARSSON, Henrik
dc.contributor.authorBOIVIN, Michel
dc.contributor.authorTREMBLAY, Richard
dc.contributor.authorCOTE, Sylvana
dc.contributor.authorCORTESE, Samuele
dc.date.accessioned2024-04-29T14:15:42Z
dc.date.available2024-04-29T14:15:42Z
dc.date.issued2023-12-01
dc.identifier.issn2352-4650en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199510
dc.description.abstractEnBACKGROUND: The co-occurrence between attention-deficit hyperactivity disorder (ADHD) and physical conditions is frequent but often goes unrecognised. Most available evidence on the links between ADHD and physical conditions relies on cross-sectional studies. Understanding temporal sequences of associations is key to inform appropriate treatment and preventive strategies. We aimed to assess possible longitudinal associations between ADHD symptoms and a broad range of physical conditions, adjusting for several confounding factors. METHODS: Participants came from the population-based Quebec Longitudinal Study of Child Development. Participants were selected from the Quebec Birth Registry, recruited between October, 1997, and July, 1998, from the province of Quebec, Canada, and followed up in early childhood (n=2120; age 5 months-5 years), middle childhood (n=1750; age 6-12 years), and adolescence (n=1573; age 13-17 years). Main outcome measures included ADHD symptom severity and physical conditions, which were reported by the person most knowledgeable of the child in early childhood, by teachers in middle childhood, and self-reported in adolescence. Multivariable regression analyses were conducted to study the prospective associations between ADHD symptoms and later physical conditions, and physical conditions and later ADHD symptoms, adjusting for multiple confounders. FINDINGS: We found several prospective associations between ADHD symptoms and physical conditions including asthma, high BMI (≥1 SD above the mean), epilepsy, dental caries, acute infections, injuries, and sleep problems. After adjusting for key confounding factors, several associations remained: ADHD symptoms in early childhood were associated with later high BMI during middle childhood (odds ratio [OR] 1·19 [95% CI 1·05-1·35]) and adolescence (OR 1·14 [1·01-1·29]), and with unintentional injuries during adolescence (OR 1·10 [1·01-1·21]). ADHD symptoms in middle childhood were significantly associated with later dental caries during adolescence (OR 1·10 [1·01-1·20]). Unintentional injuries in early childhood were associated with later ADHD symptoms in middle childhood (standardised mean difference [SMD] 0·15 [0·05-0·24]) and adolescence (SMD 0·13 [0·04-0·23]), and restless legs syndrome symptoms in middle childhood were associated with later ADHD symptoms in adolescence (SMD 0·15 [0·05-0·25]). INTERPRETATION: Our results point to the need to carefully monitor children with ADHD in early or middle childhood for several physical conditions, and to monitor children with particular physical conditions for ADHD symptoms. Our study also calls for policies to promote more integrated health-care systems for children with complex mental and physical needs, bridging the current gap between mental and physical health-care services. FUNDING: Québec Government's Ministry of Health, Ministry of Education, and Ministry of Family Affairs; The Lucie and André Chagnon Foundation; the Robert-Sauvé Research Institute of Health and Safety at Work; the Québec Statistics Institute; the Fonds de Recherche du Québec-Santé; the Fonds de Recherche du Québec-Societé et Culture; Canada's Social Science and Humanities Research Council; the Canadian Institutes of Health Research, the Sainte-Justine Research Center; and the French National Research Agency. TRANSLATION: For the French translation of the abstract see Supplementary Materials section.
dc.language.isoENen_US
dc.title.enProspective associations between ADHD symptoms and physical conditions from early childhood to adolescence: a population-based longitudinal study
dc.title.alternativeLancet Child Adolesc Healthen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/s2352-4642(23)00226-2en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed37973252en_US
bordeaux.journalThe Lancet Child & Adolescent Healthen_US
bordeaux.page863-874en_US
bordeaux.volume7en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamHEALTHY_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-04563204
hal.version1
hal.date.transferred2024-04-29T14:15:44Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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