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The antidepressant venlafaxine may act as a neurodevelopmental toxicant in cuttlefish (Sepia officinalis)

hal.structure.identifierGroupe Mémoire et Plasticité comportementale [GMPc]
dc.contributor.authorBIDEL, Flavie
hal.structure.identifierGroupe Mémoire et Plasticité comportementale [GMPc]
dc.contributor.authorDI POI, Carole
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorBUDZINSKI, Hélène
ORCID: 0000-0003-1028-9154
IDREF: 070478090
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorPARDON, Patrick
hal.structure.identifierGroupe Mémoire et Plasticité comportementale [GMPc]
dc.contributor.authorCALLEWAERT, William
hal.structure.identifierMcGill University = Université McGill [Montréal, Canada]
dc.contributor.authorARINI, Adeline
hal.structure.identifierMcGill University = Université McGill [Montréal, Canada]
dc.contributor.authorBASU, Niladri
hal.structure.identifierGroupe Mémoire et Plasticité comportementale [GMPc]
dc.contributor.authorDICKEL, Ludovic
hal.structure.identifierGroupe Mémoire et Plasticité comportementale [GMPc]
dc.contributor.authorBELLANGER, Cécile
hal.structure.identifierGroupe Mémoire et Plasticité comportementale [GMPc]
dc.contributor.authorJOZET-ALVES, Christelle
dc.date.accessioned2024-04-25T07:39:23Z
dc.date.available2024-04-25T07:39:23Z
dc.date.issued2016-07
dc.identifier.issn0161-813X
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199334
dc.description.abstractEnThe Serotonin/Norepinephrine Reuptake Inhibitor (SNRI) antidepressant venlafaxine (VEN, Effexor (R)) has become one of the most common antidepressants detected in North American and European streams. Mammalian research has established that VEN exposure is associated with a range of structural, neurochemical, and functional alterations of the brain in adults and newborns. However, the neurodevelopmental effects of VEN on non-target organisms have never been investigated. The aim of our research was to decrease this gap in knowledge by characterizing the effects of VEN exposure on a cephalopod mollusk, the common cuttlefish Sepia officinalis. This species inhabits VEN-contaminated waters and possesses an unusually sophisticated brain. These characteristics render it a unique invertebrate species for studying the neurodevelopmental effects of VEN. Cuttlefish were exposed to environmentally-relevant concentrations of VEN (Measured concentrations approximate to 5 and 100 ng L-1) or to filtered natural seawater (control) in a closed-loop system with regular water changes during the first 20 days after hatching. We evaluated brain maturation as well as neurochemical changes and behavioral performances during this critical period of development. Our results show that both VEN-exposed groups exhibited a decrease in norepinephrine levels, along with a reduction in the relative number of glutamate NMDA-like receptors binding sites in the group exposed to 5 ng L-1 of VEN after 20 days of exposure. Brain regional changes in cellular proliferation were observed in VEN-exposed groups in the vertical lobe (i.e. a key structure involved in cognitive processes) and in the optic lobes (i.e. main visual processing centers) in the absence of significant change in their volume. Along with these neurodevelopmental changes, 20 days of exposure to 100 ng L-1 of VEN was associated with a decrease in camouflage ability. Overall, our study suggests that VEN is a neurodevelopmental toxicant in non-target aquatic organisms at environmentally-relevant concentrations. (C) 2016 Elsevier B.V. All rights reserved.
dc.language.isoen
dc.publisherElsevier
dc.subject.enadult neurogenesis
dc.subject.enBrain maturation
dc.subject.encamouflage
dc.subject.enCell proliferation
dc.subject.enCephalopods
dc.subject.enenvironmentally relevant concentrations
dc.subject.enfluoxetine prozac
dc.subject.enhippocampal neurogenesis
dc.subject.enInhibitor (SNRI)
dc.subject.enmercury exposure
dc.subject.enmonoamine-oxidase activity
dc.subject.enMonoamines
dc.subject.ennervous-system
dc.subject.ennorepinephrine transporters
dc.subject.enpimephales-promelas
dc.subject.enSerotonin/Norepinephrine Reuptake
dc.subject.entransporter binding profile
dc.title.enThe antidepressant venlafaxine may act as a neurodevelopmental toxicant in cuttlefish (Sepia officinalis)
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuro.2016.05.023
dc.subject.halSciences cognitives/Neurosciences
dc.subject.halSciences du Vivant [q-bio]
dc.subject.halSciences du Vivant [q-bio]/Biologie animale/Zoologie des invertébrés
bordeaux.journalNeuroToxicologyen_US
bordeaux.page142--153
bordeaux.volume55
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeaux
bordeaux.institutionCNRS
bordeaux.peerReviewedoui
bordeaux.import.sourcehal
hal.identifierhal-01472650
hal.version1
hal.popularnon
hal.audienceInternationale
hal.exportfalse
workflow.import.sourcehal
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=NeuroToxicology&rft.date=2016-07&rft.volume=55&rft.spage=142--153&rft.epage=142--153&rft.eissn=0161-813X&rft.issn=0161-813X&rft.au=BIDEL,%20Flavie&DI%20POI,%20Carole&BUDZINSKI,%20H%C3%A9l%C3%A8ne&PARDON,%20Patrick&CALLEWAERT,%20William&rft.genre=article


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