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Are antioxidant and transcriptional responses useful for discriminating between chemo- and radiotoxicity of uranium in the crayfish Procambarus clarkii?
| dc.rights.license | open | en_US |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | AL KADDISSI, Simone | |
| dc.contributor.author | FRELON, Sandrine | |
| dc.contributor.author | ELIA, Antonia-Concetta | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | LEGEAY, Alexia | |
| hal.structure.identifier | Environnements et Paléoenvironnements OCéaniques [EPOC] | |
| dc.contributor.author | GONZALEZ, Patrice
ORCID: 0000-0003-2628-2993 IDREF: 14341917X | |
| dc.contributor.author | COPPIN, Frédéric | |
| dc.contributor.author | ORJOLLET, Daniel | |
| dc.contributor.author | CAMILLERI, Virginie | |
| dc.contributor.author | BEAUGELIN-SEILLER, Karine | |
| dc.contributor.author | GILBIN, Rodolphe | |
| dc.contributor.author | SIMON, Olivier | |
| dc.date.accessioned | 2024-04-16T09:16:24Z | |
| dc.date.available | 2024-04-16T09:16:24Z | |
| dc.date.issued | 2012-04-11 | |
| dc.identifier.issn | 0147-6513 | en_US |
| dc.identifier.uri | https://www.researchgate.net/publication/224036862_Are_antioxidant_and_transcriptional_responses_useful_for_discriminating_between_chemo-_and_radiotoxicity_of_uranium_in_the_crayfish_Procambarus_clarkii | |
| dc.identifier.uri | oai:researchgate.net:224036862 | |
| dc.identifier.uri | oai:crossref.org:10.1016/j.ecoenv.2012.03.010 | |
| dc.identifier.uri | orcid:0000-0002-7750-6339:10.1016/j.ecoenv.2012.03.010 | |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/199081 | |
| dc.description.abstractEn | The main objectives of this study were to evaluate uranium (U) toxicity in the crayfish Procambarus clarkii at a low dose of exposure and to discriminate between the chemotoxicity and radiotoxicity of U. We conducted two sets of experiments using either 30 μg L(-1) of depleted uranium (DU) or (233)U, which differ from each other only in their specific activity (DU=1.7×10(4)Bqg(-1), (233)U=3.57×10(8)Bqg(-1)). The endpoints were oxidative stress responses and mitochondrial functioning in the gills and hepatopancreas, which were measured in terms of enzyme activities and gene expression levels. U accumulation levels were measured in different organs (gills, hepatopancreas, stomach, intestine, green gland, muscles, and carapace), and internal dose rates in the hepatopancreas were compared after DU and (233)U exposures. Significant U accumulation occurred in the organs of P. clarkii, and mitochondrial damage and antioxidant responses were detected. Despite the huge difference (21,000×) in the specific activities of DU and (233)U, few significant differences in biological responses were detected in P. clarkii exposed to these two pollutants. This finding indicates that the radiotoxicity was low compared to the chemotoxicity under our exposure conditions. Finally, genes expression levels were more sensitive markers of U toxicity than enzyme activities. | |
| dc.language.iso | EN | en_US |
| dc.source | researchgate | |
| dc.source | crossref | |
| dc.source | orcid | |
| dc.title.en | Are antioxidant and transcriptional responses useful for discriminating between chemo- and radiotoxicity of uranium in the crayfish Procambarus clarkii? | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.ecoenv.2012.03.010 | en_US |
| dc.subject.hal | Sciences de l'environnement | en_US |
| bordeaux.journal | Ecotoxicology and Environmental Safety | en_US |
| bordeaux.page | 266-272 | en_US |
| bordeaux.volume | 80 | en_US |
| bordeaux.hal.laboratories | EPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.team | EA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.import.source | dissemin | |
| hal.popular | non | en_US |
| hal.audience | Internationale | en_US |
| hal.export | false | |
| workflow.import.source | dissemin | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ecotoxicology%20and%20Environmental%20Safety&rft.date=2012-04-11&rft.volume=80&rft.spage=266-272&rft.epage=266-272&rft.eissn=0147-6513&rft.issn=0147-6513&rft.au=AL%20KADDISSI,%20Simone&FRELON,%20Sandrine&ELIA,%20Antonia-Concetta&LEGEAY,%20Alexia&GONZALEZ,%20Patrice&rft.genre=article |
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