Afficher la notice abrégée

Effects of uranium on crayfish Procambarus clarkii mitochondria and antioxidants responses after chronic exposure: What have we learned?

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorAL KADDISSI, Simone
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLEGEAY, Alexia
dc.contributor.authorELIA, Antonia Concetta
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorCAMILLERI, Virginie
dc.contributor.authorGILBIN, Rodolphe
dc.contributor.authorSIMON, Olivier
dc.date.accessioned2024-04-16T08:55:24Z
dc.date.available2024-04-16T08:55:24Z
dc.date.issued2011-12-07
dc.identifier.issn0147-6513en_US
dc.identifier.urihttps://www.researchgate.net/publication/51864353_Effects_of_uranium_on_crayfish_Procambarus_clarkii_mitochondria_and_antioxidants_responses_after_chronic_exposure_What_have_we_learned
dc.identifier.urioai:crossref.org:10.1016/j.ecoenv.2011.11.026
dc.identifier.urioai:researchgate.net:51864353
dc.identifier.uriorcid:0000-0002-7750-6339:10.1016/j.ecoenv.2011.11.026
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199077
dc.description.abstractEnWe examined the impacts of Uranium (U) on mitochondria and on the response of antioxidants in the gills and the hepatopancreas of crayfish Procambarus clarkii after long-term exposure (30 and 60 days) to an environmentally relevant concentration (30 μg U/L). The expression of mitochondrial genes (12s, atp6, and cox1), as well as the genes involved in oxidative stress responses (sod(Mn) and mt) were evaluated. The activities of antioxidant enzymes (SOD, CAT, GPX and GST) were also studied. U accumulation in organs induced changes in genes' expression. The evolution of these transcriptional responses and differences between gene expression levels at high and low doses of exposure were also discussed. This study demonstrated that, after long-term exposure, U caused a decrease in antioxidant activities and induced oxidative stress. A possible ROS-mediated U cytotoxic mechanism is proposed. Expression levels of the investigated genes can possibly be used as a tool to evaluate U toxicity and seem to be more sensitive than the enzymatic activities. However a multiple biomarker approach is recommended as the perturbed pathways and the mode of action of this pollutant are not completely understood.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceresearchgate
dc.sourceorcid
dc.title.enEffects of uranium on crayfish Procambarus clarkii mitochondria and antioxidants responses after chronic exposure: What have we learned?
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ecoenv.2011.11.026en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEcotoxicology and Environmental Safetyen_US
bordeaux.page218-224en_US
bordeaux.volume78en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ecotoxicology%20and%20Environmental%20Safety&rft.date=2011-12-07&rft.volume=78&rft.spage=218-224&rft.epage=218-224&rft.eissn=0147-6513&rft.issn=0147-6513&rft.au=AL%20KADDISSI,%20Simone&LEGEAY,%20Alexia&ELIA,%20Antonia%20Concetta&GONZALEZ,%20Patrice&CAMILLERI,%20Virginie&rft.genre=article


Fichier(s) constituant ce document

Thumbnail
Nom:
Al kaddissi et al, EES3.pdf
Taille:
267.4Ko
Format:
PDF
Voir/Ouvrir

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée