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Effects of uranium uptake on transcriptional responses, histological structures and survival rate of the crayfish Procambarus clarkii

dc.rights.licenseopenen_US
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorAL KADDISSI, Simone
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorLEGEAY, Alexia
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorFLORIANI, Magali
dc.contributor.authorCAMILLERI, Virginie
dc.contributor.authorGILBIN, Rodolphe
dc.contributor.authorSIMON, Olivier
dc.date.accessioned2024-04-16T08:45:33Z
dc.date.available2024-04-16T08:45:33Z
dc.date.issued2011-07-06
dc.identifier.issn0147-6513en_US
dc.identifier.urihttps://www.researchgate.net/publication/51478729_Effects_of_uranium_uptake_on_transcriptional_responses_histological_structures_and_survival_rate_of_the_crayfish_Procambarus_clarkii
dc.identifier.urioai:researchgate.net:51478729
dc.identifier.urioai:crossref.org:10.1016/j.ecoenv.2011.06.010
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199074
dc.description.abstractEnThis work aims to investigate the accumulation levels and effects (transcriptional responses, histopathology and survival rate) associated with a wide range of dissolved uranium (U) concentrations (0, 0.03, 0.6, 4 and 8 mg/L of U) on adult male crayfish Procambarus clarkii during 4 (T4) and 10 (T10) days of exposure. The follow-up of the crayfish mortality showed that P. clarkii was highly resistant to U. Increasing waterborne U concentrations led to increasing bioaccumulation in key crayfish organs and increasing histological damages. U distribution in tissues was also evaluated using transmission electron microscopy and showed the presence of a detoxified form of U in the gill's epithelium in the shape of flakes. Expression levels of mitochondrial genes (cox1, atp6 and 12S gene) and genes involved in oxidative stress (sod(Mn) and mt) were examined together with the housekeeping gene 18S. atp6 and mt genes of P. clarkii were cloned and sequenced before analysis. Significant correlations were observed between U bioaccumulation and the down-regulation of both cox1 and sod(Mn) genes. This work provides a first U toxicogenomic and histopathological pattern of P. clarkii, identify U biomarkers and associate gene expression endpoints to accumulation levels. It also provides new insights into the mechanisms involved in U stress.
dc.language.isoENen_US
dc.sourceresearchgate
dc.sourcecrossref
dc.title.enEffects of uranium uptake on transcriptional responses, histological structures and survival rate of the crayfish Procambarus clarkii
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ecoenv.2011.06.010en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalEcotoxicology and Environmental Safetyen_US
bordeaux.page1800-1807en_US
bordeaux.volume74en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue7en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Ecotoxicology%20and%20Environmental%20Safety&rft.date=2011-07-06&rft.volume=74&rft.issue=7&rft.spage=1800-1807&rft.epage=1800-1807&rft.eissn=0147-6513&rft.issn=0147-6513&rft.au=AL%20KADDISSI,%20Simone&LEGEAY,%20Alexia&GONZALEZ,%20Patrice&FLORIANI,%20Magali&CAMILLERI,%20Virginie&rft.genre=article


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