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Biomarker responses in polar cod (Boreogadus saida) exposed to the water soluble fraction of crude oil

dc.rights.licenseopenen_US
dc.contributor.authorNAHRGANG, Jasmine
dc.contributor.authorCAMUS, Lionel
dc.contributor.authorCARLS, Mark G.
hal.structure.identifierEnvironnements et Paléoenvironnements OCéaniques [EPOC]
dc.contributor.authorGONZALEZ, Patrice
ORCID: 0000-0003-2628-2993
IDREF: 14341917X
dc.contributor.authorJÖNSSON, Martina
dc.contributor.authorTABAN, Ingrid C.
dc.contributor.authorBECHMANN, Renée K.
dc.contributor.authorCHRISTIANSEN, Jørgen S.
dc.contributor.authorHOP, Haakon
dc.date.accessioned2024-04-16T08:00:30Z
dc.date.available2024-04-16T08:00:30Z
dc.date.issued2010-05-01
dc.identifier.issn0166-445Xen_US
dc.identifier.urihttp://www.researchgate.net/publication/223769636_Biomarker_responses_in_polar_cod_(Boreogadus_saida)_exposed_to_the_water_soluble_fraction_of_crude_oil
dc.identifier.urioai:crossref.org:10.1016/j.aquatox.2009.11.003
dc.identifier.urioai:researchgate.net:223769636
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/199068
dc.description.abstractEnIn order to mimic the biological effects of an oil spill in Arctic waters, we examined several types of biomarkers (genes, enzymes, metabolites, and DNA damage) in polar cod Boreogadus saida experimentally exposed to the water soluble fractions of crude oil. During 4 weeks of exposure, induction of the studied biomarkers exceeded baseline levels. The mRNA expression of the cytochrome P4501A1 (cyp1a1) gene was the most promising biomarker, with glutathione S-transferase (gst) as a suitable complement. The delayed ethoxyresorufin O-deethylase (EROD) and GST activities and their persistence following 2 weeks of depuration may allow detection of previous exposures in field samples. The composition of PAH metabolites in the bile indicated the bioavailability of different PAH size-classes. Although mRNA expressions of antioxidant defense genes were induced at start of the exposure, with the strongest responses from catalase and cytosolic superoxide dismutase, they were poor for oil monitoring purposes due to their very short response times. Significant DNA damage demonstrated genotoxicity even at low PAH concentrations (<15 μg L−1) and was correlated with benzo(a)pyrene and pyrene metabolites in the bile.
dc.language.isoENen_US
dc.sourcecrossref
dc.sourceresearchgate
dc.title.enBiomarker responses in polar cod (Boreogadus saida) exposed to the water soluble fraction of crude oil
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.aquatox.2009.11.003en_US
dc.subject.halSciences de l'environnementen_US
bordeaux.journalAquatic Toxicologyen_US
bordeaux.page234-242en_US
bordeaux.volume97en_US
bordeaux.hal.laboratoriesEPOC : Environnements et Paléoenvironnements Océaniques et Continentaux - UMR 5805en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.teamEAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-04547834
hal.version1
hal.date.transferred2024-04-16T08:00:32Z
hal.popularnonen_US
hal.audienceInternationaleen_US
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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